Insulinemia and Blood Pressure Relationships in Patients with Primary and Secondary Hypertension, and With or Without Glucose Metabolism Impairment
| Autor: | Gavino Pisanu, Adolfo Pacifico, Marigliano A, L A Sechi, R. Tedde, A. Pala |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Mean arterial pressure Secondary hypertension Blood Pressure Essential hypertension Body Mass Index Renovascular hypertension Impaired glucose tolerance Internal medicine Diabetes mellitus Internal Medicine medicine Humans Insulin Aged business.industry Fasting Glucose Tolerance Test Middle Aged medicine.disease Glucose Hypertension Renovascular Mean blood pressure Blood pressure Endocrinology Diabetes Mellitus Type 2 Evaluation Studies as Topic Hypertension Female Insulin Resistance business |
| Zdroj: | American Journal of Hypertension. 3:521-526 |
| ISSN: | 1941-7225 0895-7061 |
| DOI: | 10.1093/ajh/3.7.521 |
| Popis: | In order to investigate the relationships between insulinemia and hypertension, fasting insulinemia has been assessed in 117 subjects: 69 normotensive subjects, 36 with essential hypertension, and 12 with renovascular hypertension, all untreated and newly diagnosed, classified in subgroups (euglycemic nonobese, euglycemic obese, with impaired glucose tolerance and with non-insulin-dependent diabetes mellitus). In the patients with essential hypertension fasting insulinemia was significantly higher than in normotensive subjects (P less than .0005). The patients with secondary hypertension and the normotensive subjects had similar fasting insulinemia values. In each subgroup fasting insulinemia was higher in hypertensive patients than among normotensive subjects (P less than .05). A significant correlation between fasting insulinemia and mean blood pressure has been found in patients with essential hypertension (r = 0.408, P less than .05), but not in patients with renovascular hypertension. Our data suggest a possible direct relationship between fasting insulinemia and blood pressure, especially in obese patients or patients with impaired glucose metabolism, and that increased blood pressure per se is not an insulin resistant state. |
| Databáze: | OpenAIRE |
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