P02.117. Genomic expression changes underlying mind-body practices
| Autor: | Jeff C. Huffman, Randall M. Zusman, Lauren E. Slipp, Manoj Bhasin, Matthew A. Scult, Herbert Benson, Jeffery A. Dusek, Bei-Hung Chang, Towia A. Libermann, Gregory L. Fricchione, John W. Denninger, B Mahoney |
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| Rok vydání: | 2012 |
| Předmět: |
0303 health sciences
Gene ontology business.industry lcsh:Other systems of medicine General Medicine Computational biology lcsh:RZ201-999 Peripheral blood mononuclear cell 03 medical and health sciences 0302 clinical medicine Differentially expressed genes Text mining Complementary and alternative medicine 030220 oncology & carcinogenesis Poster Presentation Medicine business Gene 030304 developmental biology |
| Zdroj: | BMC Complementary and Alternative Medicine, Vol 12, Iss Suppl 1, p P173 (2012) Europe PubMed Central BMC Complementary and Alternative Medicine |
| ISSN: | 1472-6882 |
| DOI: | 10.1186/1472-6882-12-s1-p173 |
| Popis: | Methods We performed transcriptional profiling analyses on the Peripheral Blood Mononuclear Cells (PBMCs) obtained before (Pre RR) and after (Post RR) 8 weeks of intervention from a pilot group of 4 hypertensives. Transcriptional profiling used Affymetrix HT HG-U133+ PM arrays, containing >47,000 transcripts corresponding to 38,500 genes. The arrays were normalized using the robust multi-chip analysis (RMA) algorithm. After normalization and preprocessing, differentially expressed genes were identified using the random variance model based t-test. To understand the underlying biological mechanisms associated with RR regulated genes, we performed Gene ontology (GO), pathways and geneset enrichment analysis (GSEA). |
| Databáze: | OpenAIRE |
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