Humoral and cellular immunity to RSV in infants, children and adults
| Autor: | C de Lara, L Silva-Reyes, Charles J. Sande, Amber J. Thompson, A Pierantoni, Andrew J. Pollard, Paul Klenerman, Stefania Capone, Christopher A Green, Alessandra Vitelli, F Napolitano |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Cellular immunity Adolescent T-Lymphocytes Respiratory Syncytial Virus Infections Antibodies Viral Virus 03 medical and health sciences Young Adult Immune system Medicine Humans Respiratory system Child B-Lymphocytes Immunity Cellular General Veterinary General Immunology and Microbiology biology business.industry Respiratory disease Public Health Environmental and Occupational Health Infant Acquired immune system medicine.disease Immunity Humoral Titer 030104 developmental biology Infectious Diseases Child Preschool Respiratory Syncytial Virus Human Immunology biology.protein Molecular Medicine Female Antibody business Immunologic Memory |
| Zdroj: | Vaccine. 36(41) |
| ISSN: | 1873-2518 |
| Popis: | Background Respiratory syncytial virus (RSV) causes respiratory disease throughout life. Here we report differences in naturally acquired immunity with age and presumed exposure. Methods A longitudinal, non-interventional, observational study was performed in healthy adults (20 paediatric healthcare workers and 10 non-healthcare workers), children (10 aged 3–6 years) and infants (5 aged 2–4 months and 20 aged 6–12 months). Blood samples were analysed for RSV-neutralising antibody titre, F/Ga/Gb-specific antibody titres, F-specific IgG/IgA memory B-cell frequencies and T-cell production of IFNγ, IL-4, IL-13 and IL-17. Results Serum G-specific antibody titres were significantly lower in infants and children than adults. However, serum titres of F-specific and RSV-neutralising antibody and IFNγ-producing T-cell frequencies were low or absent in the infants, but comparable between children and adults. Interestingly, F-specific memory IgA B-cells could not be detected in paediatric samples and in samples from non-healthcare workers, but recordable IgA memory B-cells were found in 9/18 paediatric healthcare workers and 2/8 non-healthcare workers at the end of the RSV season. These responses waned 4–6 months later. By contrast, F-specific IgG memory B-cells were detectable in samples from all adults without significant variation across time points. T-cells producing IL-4, IL-13 and IL-17 responses were not detectable in peripheral blood from a subset of volunteers. ConclusionsRepeated RSV exposure in early life generates immune responses that are inversely related to frequency of severe disease. Induction of F-specific antibody and cellular immune responses through infant vaccination might help to accelerate the development of protective immune responses at an early age. |
| Databáze: | OpenAIRE |
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