Systemic inflammatory response to non-surgical treatment in hypertensive patients with periodontal infection
| Autor: | María José Saenz Martínez, Catalina Latorre Uriza, Federico José Hernández Meza, Mariella Del Hierro Rada, Juliana Velosa-Porras, Nelly S Roa, Francina María Escobar Arregocés |
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| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty hypertension medicine.medical_treatment periodontal disease Observational Study Inflammation Blood Pressure Gastroenterology Proinflammatory cytokine Root Planing 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance periodontal infection Internal medicine periodontal debridement Medicine Humans 030212 general & internal medicine Endothelial dysfunction Periodontitis Triglycerides mediators of inflammation business.industry General Medicine Middle Aged medicine.disease Systemic Inflammatory Response Syndrome cytokines Blood Cell Count Vascular endothelial growth factor Cytokine Blood pressure Cholesterol Treatment Outcome chemistry 030220 oncology & carcinogenesis Dental Scaling Female medicine.symptom business Biomarkers Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Hypertension is associated with chronic inflammation in the tissues and organs that are involved in the regulation of arterial pressure, such as kidneys and blood vessels. Periodontal disease affects systemic inflammatory markers, leading to endothelial dysfunction, atherosclerotic plaque instability, dyslipidaemia, and insulin resistance. These conditions can also cause an increase in the blood pressure. Nonsurgical periodontal therapies, such as scaling and root planning, can affect systemic markers of inflammation. We evaluated the effect of scaling and root planning on serum levels of inflammation biomarkers in hypertensive patients. The sample consisted of 19 hypertensive patients with Periodontitis. The patients underwent laboratory tests that included glycaemia, cholesterol, triglycerides and blood count. Blood pressure was measured before periodontal therapy, and the second blood pressure recording was obtained at the re-evaluation appointment. Quantification of peripheral blood cytokines was performed using the Milliplex Inflammation Human Cytokine kit (Interleukin 1-β, Interleukin-4, Interleukin-6, Interleukin-8, Interleukin-10, Interleukin-12 P70, Interleukin-17A, vascular endothelial growth factor and tumor necrosis factor-alpha). All cytokine levels decreased from the initial examination to reassessment. Cytokines that reflected a statistically significant difference included Interleukin-1β and endothelial vascular growth factor (P = .04 and P = .004). Hypertensive patients with periodontitis undergoing non-surgical periodontal treatment exhibited a decrease in proinflammatory cytokine levels. Non-surgical periodontal treatment decreases the levels of systemic proinflammatory cytokines in controlled hypertensive patients. |
| Databáze: | OpenAIRE |
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