Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors: EPIC-CVD case-cohort study
Autor: | Melony C Fortuin-de Smidt, Maquins Odhiambo Sewe, Camille Lassale, Elisabete Weiderpass, Jonas Andersson, José María Huerta, Ulf Ekelund, Krasimira Aleksandrova, Tammy YN Tong, Christina C Dahm, Anne Tjønneland, Cecilie Kyrø, Karen Steindorf, Matthias B Schulze, Verena Katzke, Carlotta Sacerdote, Claudia Agnoli, Giovanna Masala, Rosario Tumino, Salvatore Panico, Jolanda MA Boer, N Charlotte Onland-Moret, GC Wanda Wendel-Vos, Yvonne T van der Schouw, Kristin Benjaminsen Borch, Antonio Agudo, Dafina Petrova, María Dolores Chirlaque, Moreno Iribas Conchi, Pilar Amiano, Olle Melander, Alicia K Heath, Dagfinn Aune, Nita G Forouhi, Claudia Langenberg, Soren Brage, Elio Riboli, Nicholas J Wareham, John Danesh, Adam S Butterworth, Patrik Wennberg |
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Přispěvatelé: | Forouhi, Nita [0000-0002-5041-248X], Langenberg, Claudia [0000-0002-5017-7344], Brage, Soren [0000-0002-1265-7355], Wareham, Nicholas [0000-0003-1422-2993], Danesh, John [0000-0003-1158-6791], Butterworth, Adam [0000-0002-6915-9015], Apollo - University of Cambridge Repository |
Rok vydání: | 2022 |
Předmět: |
Adult
Cardiac & Cardiovascular Systems population preventable fraction Epidemiology Hypercholesterolemia QUESTIONNAIRE physical activity BLOOD-PRESSURE EXERCISE Coronary Disease ALL-CAUSE Cohort Studies Risk Factors Humans risk factors Obesity Prospective Studies coronary heart disease Exercise POPULATION Science & Technology Physical activity MORTALITY Incidence Public Health Global Health Social Medicine and Epidemiology ASSOCIATION PREVENTION case-cohort study Coronary heart disease Population preventable fraction Risk factors Case-cohort study Folkhälsovetenskap global hälsa socialmedicin och epidemiologi CARDIOVASCULAR-DISEASE Hypertension Cardiovascular System & Cardiology LIFE-STYLE Cardiology and Cardiovascular Medicine Life Sciences & Biomedicine |
Zdroj: | Fortuin-de Smidt, M C, Sewe, M O, Lassale, C, Weiderpass, E, Andersson, J, Huerta, J M, Ekelund, U, Aleksandrova, K, Tong, T Y, Dahm, C C, Tjønneland, A, Kyrø, C, Steindorf, K, Schulze, M B, Katzke, V, Sacerdote, C, Agnoli, C, Masala, G, Tumino, R, Panico, S, Boer, J M, Onland-Moret, N C, Wendel-Vos, G W, van der Schouw, Y T, Borch, K B, Agudo, A, Petrova, D, Chirlaque, M-D, Conchi, M-I, Amiano, P, Melander, O, Heath, A K, Aune, D, Forouhi, N G, Langenberg, C, Brage, S, Riboli, E, Wareham, N J, Danesh, J, Butterworth, A S & Wennberg, P 2022, ' Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors : EPIC-CVD case-cohort study ', European Journal of Preventive Cardiology, vol. 29, no. 12, zwac055 . https://doi.org/10.1093/eurjpc/zwac055 Fortuin-de Smidt, M C, Sewe, M O, Lassale, C, Weiderpass, E, Andersson, J, Huerta, J M, Ekelund, U, Aleksandrova, K, Tong, T Y, Dahm, C C, Tjønneland, A, Kyrø, C, Steindorf, K, Schulze, M B, Katzke, V, Sacerdote, C, Agnoli, C, Masala, G, Tumino, R, Panico, S, Boer, J M, Onland-Moret, N C, Wendel-Vos, G W, van der Schouw, Y T, Borch, K B, Agudo, A, Petrova, D, Chirlaque, M-D, Conchi, M-I, Amiano, P, Melander, O, Heath, A K, Aune, D, Forouhi, N G, Langenberg, C, Brage, S, Riboli, E, Wareham, N J, Danesh, J, Butterworth, A S & Wennberg, P 2022, ' Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors : EPIC-CVD case-cohort study ', European Journal of Preventive Cardiology, vol. 29, no. 11, pp. 1618–1629 . https://doi.org/10.1093/eurjpc/zwac055 European journal of preventive cardiology, 29(12):1618-1629 European Journal of Preventive Cardiology (EJPC) |
ISSN: | 2047-4881 2047-4873 |
Popis: | Aims This study aimed to evaluate the association between physical activity and the incidence of coronary heart disease (CHD) in individuals with and without CHD risk factors. Methods and results EPIC-CVD is a case-cohort study of 29 333 participants that included 13 582 incident CHD cases and a randomly selected sub-cohort nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Self-reported physical activity was summarized using the Cambridge physical activity index (inactive, moderately inactive, moderately active, and active). Participants were categorized into sub-groups based on the presence or the absence of the following risk factors: obesity (body mass index ≥30 kg/m2), hypercholesterolaemia (total cholesterol ≥6.2 mmol/L), history of diabetes, hypertension (self-reported or ≥140/90 mmHg), and current smoking. Prentice-weighted Cox regression was used to assess the association between physical activity and incident CHD events (non-fatal and fatal). Compared to inactive participants without the respective CHD risk factor (referent), excess CHD risk was highest in physically inactive and lowest in moderately active participants with CHD risk factors. Corresponding excess CHD risk estimates amongst those with obesity were 47% [95% confidence interval (CI) 32–64%] and 21% (95%CI 2–44%), with hypercholesterolaemia were 80% (95%CI 55–108%) and 48% (95%CI 22–81%), with hypertension were 80% (95%CI 65–96%) and 49% (95%CI 28–74%), with diabetes were 142% (95%CI 63–260%), and 100% (95%CI 32–204%), and amongst smokers were 152% (95%CI 122–186%) and 109% (95%CI 74–150%). Conclusions In people with CHD risk factors, moderate physical activity, equivalent to 40 mins of walking per day, attenuates but does not completely offset CHD risk. |
Databáze: | OpenAIRE |
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