Predictors of Disease Recurrence Post Living Donor Liver Transplantation in End Stage Chronic HCV Patients

Autor: Mostafa K. El Awady, Moataza H Omran, Shereen Shoukry Hunter, Ashraf O. Abdel Aziz, Tamer Elbaz, Tawfeek H. Abdelhafez, Noha G Bader El Din, Mahmoud Abdel Aziz Riad, Reham M. Dawood
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Graft Rejection
Male
medicine.medical_treatment
Hepacivirus
Clinical Biochemistry
Interleukin-1beta
Liver transplantation
Gastroenterology
Recurrence
2'
5'-Oligoadenylate Synthetase
Living Donors
Young adult
Stage (cooking)
lcsh:R5-920
biology
Coinfection
Age Factors
General Medicine
Middle Aged
Viral Load
Immunosuppressive drug
Cytomegalovirus Infections
RNA
Viral
Female
lcsh:Medicine (General)
Viral load
Immunosuppressive Agents
Research Article
Adult
medicine.medical_specialty
Adolescent
Article Subject
Polymorphism
Single Nucleotide
Disease-Free Survival
Young Adult
Internal medicine
Genetics
medicine
Humans
Molecular Biology
Genetic Association Studies
Proportional Hazards Models
Proportional hazards model
Interleukins
Biochemistry (medical)
Hepatitis C
Chronic
biology.organism_classification
medicine.disease
digestive system diseases
Liver Transplantation
Immunology
Interferons
Biomarkers
Zdroj: Disease Markers, Vol 2014 (2014)
Disease Markers
ISSN: 0278-0240
DOI: 10.1155/2014/202548
Popis: HCV recurrence represents a universal phenomenon after liver transplantation. In this study Fifty HCV patients who underwent living donor liver transplantation were enrolled and factors that may accelerate HCV reinfection of the allograft such as donor’s age and degree of liver steatosis, recipient’s age, gender, BMI, MELD score, liver functions, HCV viral load, type of immunosuppressive drug, and genetic polymorphisms of IL28B, OAS, and IL1B were studied. The results of disease-free survival (DFS) rates showed inverse correlation with the recipient’s postoperative levels of ALT, AST, ALP (P<0.001, P<0.003and P<0.025). However, SNPs in OAS and IL1B genes had no apparent correlation with DFS. Cox proportional hazards model revealed that patients with elevated levels of ALT, preoperative viral titers, IL28B CT, and IL28B TT were 8.28, 4.22, 3.35, and 1.36 times, respectively, more likely to develop recurrence. In conclusion IL28B SNP, ALT level, and preoperative HCV titer besides proper choice of immunosuppressant are helpful for predicting posttransplant HCV recurrence and DFS.
Databáze: OpenAIRE
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