Protective effects of skin permeable epidermal and fibroblast growth factor against ultraviolet-induced skin damage and human skin wrinkles
| Autor: | Sang Ho Jang, Kyu Huyng Han, Yong-Jun Cho, Jae Jin An, Hyuck Se Kwon, Soo Young Choi, Jae Sook Koh, Soo Yun Lee, Jinseu Park, Ji Hwoon Baek, Dae Won Kim, Won Sik Eum |
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| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty Ultraviolet Rays Human skin Dermatology Biology Fibroblast growth factor Immunofluorescence Mice medicine Animals Humans Wrinkle Skin Epidermal Growth Factor integumentary system medicine.diagnostic_test Cell growth Regeneration (biology) FGF1 Skin Aging Mice Inbred C57BL Blot Disease Models Animal Treatment Outcome Cancer research Fibroblast Growth Factor 1 Dermatologic Agents medicine.symptom hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Cosmetic Dermatology. 12:287-295 |
| ISSN: | 1473-2130 |
| Popis: | SummaryBackground Epidermal and fibroblast growth factor (EGF and FGF1) proteins play an important role in the regeneration and proliferation of skin cells. EGF and FGF1 have considerable potential as possible therapeutic or cosmetic agents for the treatment of skin damage including wrinkles. Objectives Using protein transduction domains (PTD), we investigated whether PTD-EGF and FGF1 transduced into skin cells and tissue. Transduced proteins showed protective effects in a UV-induced skin damage model as well as against skin wrinkles. Methods Transduced PTD-EGF and FGF1 proteins were detected by immunofluorescence and immunohistochemistry. The effects of PTD-EGF and FGF1 were examined by WST assay, Western blotting, immunohistochemistry, and skin wrinkle parameters. Results The PTD-EGF and FGF1 increased cell proliferation and collagen type 1 alpha 1 protein accumulation in skin tissue. Also, PTD-EGF and FGF1 inhibited UV-induced skin damage. Furthermore, topical application of PTD-EGF and FGF1 contained ampoules which were considered to improve the wrinkle parameters of human skin. Conclusion These results show that PTD-EGF and FGF1 can be a potential therapeutic or cosmetic agent for skin damaged and injury including wrinkles and aging. |
| Databáze: | OpenAIRE |
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