Hydroxyproline Content and Fibrogenesis in Mouse Liver and Lungs during the Early Stages of BCG Granulomatosis
| Autor: | L. A. Cherdantseva, L. B. Kim, V. A. Shkurupiy, I. K. Nikonova, O. V. Potapova, T. V. Sharkova |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Pathology medicine.medical_specialty Granuloma Respiratory Tract Biology Lung pathology General Biochemistry Genetics and Molecular Biology Mice Hydroxyproline chemistry.chemical_compound Stress Physiological Fibrosis hemic and lymphatic diseases medicine Animals Acute stress Lung Cell Proliferation Mice Inbred BALB C Granuloma Cell growth Macrophages General Medicine Fibroblasts medicine.disease Mycobacterium bovis Liver chemistry Immunology Liver pathology |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 154:299-302 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-013-1935-5 |
| Popis: | In generalized BCG granulomatosis, fibrosis starts early (on day 3) and not only around the granulomas, but also in the organs. The severity of organ fibrosis is apparently determined by the concentration of granulomas, in particular their macrophages inducing proliferation of fibroblasts in organs and granulomas as well as activation of fibrogenesis. On day 30 after infection, the degree of fibrosis in the lungs was by 6 times higher than in the liver. The increase in hydroxyproline concentration in organs in early period of infection was determined by acute stress, while on day 30 it resulted from its enhanced synthesis by granuloma fibroblasts and resident fibroblasts in organs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink