Neutralizing antibodies after infection with dengue 1 virus
| Autor: | Gustavo Kourí, Rosmari Rodriguez-Roche, Susana Vázquez, María G. Guzmán, Ernest A. Gould, Ángel M. Álvarez, Scott B. Halstead, Mayling Alvarez, Luis Morier, Tibaire Montes, Lidice Bernardo |
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| Rok vydání: | 2007 |
| Předmět: |
Microbiology (medical)
Epidemiology viruses 030231 tropical medicine Heterologous lcsh:Medicine dengue hemorrhagic fever macromolecular substances Biology Dengue virus medicine.disease_cause Antibodies Viral Virus Dengue fever lcsh:Infectious and parasitic diseases Dengue 03 medical and health sciences 0302 clinical medicine Neutralization Tests American dengue 2 genotype medicine Humans lcsh:RC109-216 Neutralizing antibody 030304 developmental biology 0303 health sciences Research lcsh:R Antibody titer virus diseases Cuba neutralizing antibody Dengue Virus medicine.disease Virology 3. Good health Titer Infectious Diseases Immunology dengue 2 biology.protein Antibody |
| Zdroj: | Emerging Infectious Diseases Emerging Infectious Diseases, Vol 13, Iss 2, Pp 282-282 (2007) |
| ISSN: | 1080-6040 |
| Popis: | Severity of disease is markedly increased when infection with dengue virus type 2 follows infection with dengue virus type 2 by an interval of 20 years. Severity of disease is markedly increased when infection with dengue virus type 2 (DENV-2) follows infection with DENV-1. Studies have shown that heterologous neutralizing antibody titers are inversely correlated with severity of a second infection. If this mechanism controlled disease severity in Cuba, heterotypic antibody titers should have declined over time. To determine whether phenotypic changes in dengue antibodies occur over time, we analyzed serum samples collected 4–8 and 20–22 years after DENV-1 infection. We found a significant increase in mean titer of homologous DENV-1 neutralizing antibodies and a significant decrease in heterologous antibodies to 1 of 2 genotypes of DENV-2 virus (the American genotype). Asian DENV-2 viruses were not neutralized during either interval; however, the American genotype underwent phenotypic changes in heterotypic viral neutralizing antibodies in the predicted direction. This finding may be related to the time-dependent changes in severity of disease found with secondary dengue infection. |
| Databáze: | OpenAIRE |
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