Regenerative peripheral nerve interface free muscle graft mass and function
| Autor: | Jana D. Moon, Stephen W.P. Kemp, Yaxi Hu, Melanie G. Urbanchek, Elizabeth A. Mays, Ian C. Sando, Andrej Nedic, Theodore A. Kung, Zachary P French, Daniel C. Ursu, Paul S. Cederna, Racquel A Sohasky, Shoshana W. Ambani |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Physiology Neural Conduction Action Potentials Artificial Limbs Hamstring Muscles Isometric exercise 030105 genetics & heredity Signal-To-Noise Ratio 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Muscle action Peripheral nerve Physiology (medical) Peripheral nerve interface Muscle graft medicine Animals Peripheral Nerves Muscle Skeletal Muscle force Chemistry Electromyography Regeneration (biology) Skeletal muscle Peroneal Nerve Robotics Rats Inbred F344 Electrodes Implanted Rats medicine.anatomical_structure Neurology (clinical) 030217 neurology & neurosurgery Biomedical engineering Muscle Contraction |
| Zdroj: | MusclenerveREFERENCES. 63(3) |
| ISSN: | 1097-4598 |
| Popis: | Background Regenerative peripheral nerve interfaces (RPNIs) transduce neural signals to provide high-fidelity control of neuroprosthetic devices. Traditionally, rat RPNIs are constructed with ~150 mg of free skeletal muscle grafts. It is unknown whether larger free muscle grafts allow RPNIs to transduce greater signal. Methods RPNIs were constructed by securing skeletal muscle grafts of various masses (150, 300, 600, or 1200 mg) to the divided peroneal nerve. In the control group, the peroneal nerve was transected without repair. Endpoint assessments were conducted 3 mo postoperatively. Results Compound muscle action potentials (CMAPs), maximum tetanic isometric force, and specific muscle force were significantly higher for both the 150 and 300 mg RPNI groups compared to the 600 and 1200 mg RPNIs. Larger RPNI muscle groups contained central areas lacking regenerated muscle fibers. Conclusions Electrical signaling and tissue viability are optimal in smaller as opposed to larger RPNI constructs in a rat model. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text