Pediatric Patients with Adrenal Neuroblastoma: A SEER Analysis, 2004-2013
| Autor: | Shengxiang Chen, Zhongrong Li, Xiaoxiao Hu, Wenfeng Tang, Randong Yang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Male medicine.medical_specialty Prognostic variable Time Factors Adolescent Adrenal Gland Neoplasms Kaplan-Meier Estimate Malignancy 03 medical and health sciences Neuroblastoma 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Child Survival rate Survival analysis business.industry Proportional hazards model Hazard ratio Infant Newborn Infant General Medicine Nomogram medicine.disease Prognosis Survival Analysis Confidence interval Survival Rate Nomograms 030220 oncology & carcinogenesis Child Preschool Regression Analysis Female business SEER Program |
| Zdroj: | The American surgeon. 86(2) |
| ISSN: | 1555-9823 |
| Popis: | Adrenal neuroblastoma (NB) is a relatively common malignancy in children. The Surveillance, Epidemiology, and End Results database was used to present demographic data and a survival analysis with the aim of making tumor management better. The Surveillance, Epidemiology, and End Results database was used to search pediatric patients (age £16 years) with NB from 2004 to 2013. The Kaplan-Meier method was used to calculate the overall survival. And, we used Cox regression analysis to determine hazard ratios for prognostic variables. Independent prognostic factors were selected into the nomogram to predict individual's three-, five-, and seven-year overall survival. The study included a total of 1870 pediatric patients with NB in our cohort. Overall, three-, five-, and seven-year survival rates for adrenal NB were 0.777, 0.701, and 0.665, respectively, whereas the rates for nonadrenal NB were 0.891, 0.859, and 0.832, respectively. The multivariate analysis identified age >1 year, no complete resection (CR)/CR, radiation, and regional/distant metastasis as independent predictors of mortality for adrenal NB. Concordance index of the nomogram was 0.665 (95% confidence interval, 0.627–0.703). Pediatric patients with adrenal NB have significantly worse survival than those with nonadrenal NB. Adrenal NB with age |
| Databáze: | OpenAIRE |
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