A novel respiratory model of infection with monkeypox virus in cynomolgus macaques
| Autor: | Arthur J. Goff, Kenny L. Lin, Jason Paragas, Norman Kreiselmeier, Lisa E. Hensley, Carly Wlazlowski, Eric M. Mucker, Chad Foster, Jennifer Chapman, James V. Lawler, Joshua D. Shamblin |
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| Rok vydání: | 2011 |
| Předmět: |
viruses
Immunology Disease Biology Microbiology Monkeypox Virology medicine Smallpox Animals Respiratory system Monkeypox virus Respiratory Tract Infections Respiratory tract infections Respiratory infection virus diseases medicine.disease biology.organism_classification Disease Models Animal Macaca fascicularis Insect Science Pathogenesis and Immunity Viral disease |
| Zdroj: | Journal of virology. 85(10) |
| ISSN: | 1098-5514 |
| Popis: | Variola, the causative agent of smallpox, and the related monkeypox virus are both select agents that, if purposefully released, would cause public panic and social disruption. For this reason research continues in the areas of animal model and therapeutic development. Orthopoxviruses show a widely varying degree of host specificity, making development of accurate animal models difficult. In this paper, we demonstrate a novel respiratory infection technique that resulted in “classic” orthopox disease in nonhuman primates and takes the field of research one step closer to a better animal model. |
| Databáze: | OpenAIRE |
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