Immunoglobulin-G-dependent stimulation of guinea pig lung mast cells and macrophages
| Autor: | B. Boris Vargaftig, Claude Dumarey, M. Bachelet, M. Al-Laith, Nathalie Havet, A. Weyer |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Ovalbumin Guinea Pigs Immunology In Vitro Techniques Biology Immunoglobulin E Histamine Release Immunoglobulin G Guinea pig Thromboxane A2 chemistry.chemical_compound Macrophages Alveolar medicine Animals Immunology and Allergy Mast Cells Lung Receptors IgG Immunization Passive respiratory system Mast cell medicine.anatomical_structure chemistry biology.protein Female Antibody Pulmonary alveolus Histamine |
| Zdroj: | Allergy. 48:608-614 |
| ISSN: | 1398-9995 0105-4538 |
| DOI: | 10.1111/j.1398-9995.1993.tb00757.x |
| Popis: | Alveolar macrophages and mast cells isolated from guinea pig lung were passively sensitized with IgG1, IgG2, or serum obtained from guinea pigs actively sensitized with ovalbumin. The release of histamine by mast cells and of thromboxane A2 by alveolar macrophages upon ovalbumin challenge indicated that both antibodies and serum were capable of sensitizing these cells with similar effectiveness. Heating the serum at 56 degrees C for 4 h to inactivate IgE did not modify the antigen-dependent response of lung cells. These results suggest a predominant role for IgG in the allergic response of the guinea pig through the activation of different cell types such as lung mast cells and alveolar macrophages. |
| Databáze: | OpenAIRE |
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