Prostaglandin E2 synthase in syncytiotrophoblastic vesicles found in the placental intervillous space
| Autor: | Toshio Fujikura, Makio Mukai |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
musculoskeletal diseases
Placenta Pregnancy Trimester Third medicine.medical_treatment Sensitivity and Specificity Sampling Studies Syncytiotrophoblast Pregnancy medicine Humans Prostaglandin E2 Basal plate (placenta) Prostaglandin-E Synthases ATP synthase biology Vesicle Biopsy Needle Obstetrics and Gynecology Intervillous space Immunohistochemistry Molecular biology Trophoblasts Staining Intramolecular Oxidoreductases medicine.anatomical_structure Biochemistry embryonic structures biology.protein Female lipids (amino acids peptides and proteins) Chorionic Villi medicine.drug Prostaglandin E |
| Zdroj: | American Journal of Obstetrics and Gynecology. 196:361.e1-361.e4 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/j.ajog.2006.11.029 |
| Popis: | Objective The purpose of this study was to confirm microsomal prostaglandin E 2 synthase (mPGES) in the vesicles found in the intervillous space. Study Design Immunohistochemical staining for mPGES was conducted to confirm this enzyme in vesicles by using fresh sections of mature placentas. Results Staining for mPGES was prominent in vesicles separating from syncytiotrophoblast into the intervillous space. Syncytiotrophoblast was partly positive or negative for mPGES. Vesicles showed a tendency to degenerate with a weakly positive or negative reaction for mPGES. Extravillous cytotrophoblast was strongly positive for mPGES in the basal plate. Conclusion The vesicles containing mPGES suggest the formation of prostagladin E 2 (PGE 2 ). This enzyme could be concentrated in vesicles by a different secretory mechanism. |
| Databáze: | OpenAIRE |
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