The role of interneuron networks in driving human motor cortical plasticity
| Autor: | Michelle Balaratnam, N. Murase, Alkomiet Hasan, Masashi Hamada, John C. Rothwell |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Adolescent Interneuron Cognitive Neuroscience medicine.medical_treatment CTBS Individuality Inhibitory postsynaptic potential behavioral disciplines and activities Young Adult 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Interneurons Neuroplasticity medicine Humans 030304 developmental biology 0303 health sciences Neuronal Plasticity Motor Cortex Middle Aged Evoked Potentials Motor Transcranial Magnetic Stimulation Central sulcus Transcranial magnetic stimulation medicine.anatomical_structure nervous system Excitatory postsynaptic potential Female Nerve Net Psychology Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery Motor cortex |
| Zdroj: | Cerebral Cortex; Vol 23 |
| Popis: | The after-effects of repetitive transcranial magnetic stimulation (rTMS) are highly variable between individuals. Because different populations of cortical neurons are stimulated more easily or are more excitable in different people at different times, the variability may not be due to differences between individuals in the plasticity of cortical synapses, but may instead be due to individual differences in the recruitment of cortical neurons. In this study, we examined the effects of rTMS in 56 healthy volunteers. The responses to excitatory and inhibitory theta burst stimulation (TBS) protocols were highly variable between individuals. Surprisingly, the TBS effect was highly correlated with the latency of motor-evoked potentials (MEPs) evoked by TMS pulses that induced an anterior-posterior (AP) directed current across the central sulcus. Finally, we devised a new plasticity protocol using closely timed pairs of oppositely directed TMS current pulses across the central sulcus. Again, the after-effects were related to the latency of MEPs evoked by AP current. Our results are consistent with the idea that variation in response to rTMS plasticity probing protocols is strongly influenced by which interneuron networks are recruited by the TMS pulse. |
| Databáze: | OpenAIRE |
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