Is the nociceptin (NOP) receptor involved in attenuation of the expression of sensitization to morphine-induced hyperlocomotion in mice?
| Autor: | Jerzy Silberring, J. Wichmann, Tomasz Dylag, Krzysztof Rolka, Piotr Rafalski, Jolanta Kotlinska, Sylwia Talarek |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Narcotics medicine.drug_class medicine.medical_treatment NOP Drug Resistance Stimulation Pharmacology Mice medicine Animals Spiro Compounds Receptor Sensitization Morphine Chemistry Imidazoles Nociceptors Receptor antagonist Stimulant Psychiatry and Mental health Nociceptin receptor medicine.anatomical_structure Locomotion medicine.drug |
| Zdroj: | Behavioural Pharmacology. 16:101-106 |
| ISSN: | 0955-8810 |
| DOI: | 10.1097/00008877-200503000-00005 |
| Popis: | In the present study we investigated whether synthetic agonists of the nociceptin (NOP) receptors, Ro 64-6198 {(1 S,3aS)-8-(2,3,3a,4,5,6-hexahydro-1 H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4,5]decan-4-one} and Ro 65-6570 (8-acenaphthen-1-yl-1 -phenyl-1,3,8-triaza-spiro[4.5] decan-4-one), influence the expression of sensitization to the locomotor stimulant effect of morphine in mice. Sensitization was produced by five repeated administrations of morphine (10mg/kg, s.c.) at 3-day intervals. Seven days after the last morphine injection, Ro 64-6198 (1 and 3 mg/kg, i.p.) and Ro 65-6570 (3 and 6 mg/kg, i.p.) were given immediately before the challenge dose of morphine (10 mg/kg, s.c.). Both substances inhibited the expression of sensitization to the locomotor stimulant action of morphine. However, the selective NOP receptor antagonist, [Nphe 1 ]NC(1-13)NH 2 (30nmol, i.c.v.) did not reverse the inhibitory effect of the Ro-compounds. Therefore, our results suggest that the NOP receptor may not be critical for the influence of Ro-compounds on the morphine-induced sensitization, or the observed effect may be attributed to one functional subset of this receptor, stimulation of which is not blocked by [Nphe 1 ]NC (1-13)NH 2 . |
| Databáze: | OpenAIRE |
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