Quantification of intravenous contrast-enhanced Doppler power spectrum in the rabbit carotid artery
| Autor: | Donald P. Frush, Diane S. Babcock, Keith S. White, Lori L. Barr |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Materials science Acoustics and Ultrasonics Carotid arteries Perflubron emulsion Biophysics Contrast Media chemistry.chemical_compound symbols.namesake In vivo medicine Animals Radiology Nuclear Medicine and imaging Ultrasonography Doppler Color Observer Variation Intravenous contrast Fluorocarbons Ultrasonography Doppler Duplex Dose-Response Relationship Drug Radiological and Ultrasound Technology Perflubron Hemodynamics Spectral density Signal Processing Computer-Assisted Ultrasonography Doppler Image Enhancement Hydrocarbons Brominated Carotid Arteries chemistry Injections Intravenous Personal computer Data Display Linear Models symbols Emulsions Rabbits Radiology Doppler effect Software Biomedical engineering |
| Zdroj: | Ultrasound in Medicine & Biology. 21:41-47 |
| ISSN: | 0301-5629 |
| DOI: | 10.1016/0301-5629(94)00097-2 |
| Popis: | In vivo evaluation of Doppler contrast agent (DCA) enhancement has been principally qualitative. To quantitate the enhancement of the Doppler signal by perflubron emulsion, an investigational DCA, the audio-Doppler signal from the rabbit carotid artery was recorded during 0.5-ml/kg incremental doses to a total dose of 2.5 ml/kg. A representation of the recorded signal intensity, the Doppler power spectrum (DPS), was determined using a personal computer and commercially available software package. The dose related enhancement from perflubron emulsion was linear (r = 0.986, p = 0.0124) with a 710% (8.5 dB) overall enhancement at 2.5 ml/kg (p = 0.0001). Significant differences in enhancement could be detected with doses as low as 1.0 ml/kg and compared favorably with observer assessment of dose-related enhancement. This relatively simple method of computer analysis can quantify in vivo Doppler signal intensity and enhancement by perflubron emulsion and may enable quantitative comparisons between different DCAs. |
| Databáze: | OpenAIRE |
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