Pluronics: Intelligent building units for targeted cancer therapy and molecular imaging
| Autor: | Soon Hong Yuk, Chang Soon Hwang, Yong Woo Jung, Jae Hong Seo, Dal Yong Park, Da Hye Yang, Nisar Ul Khaliq, Byeong Min Yun |
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| Rok vydání: | 2018 |
| Předmět: |
Pharmaceutical Science
Antineoplastic Agents 02 engineering and technology Poloxamer 030226 pharmacology & pharmacy Krafft temperature Micelle 03 medical and health sciences chemistry.chemical_compound Surface-Active Agents 0302 clinical medicine Drug Delivery Systems Neoplasms Copolymer Animals Humans Micelles Ethylene oxide technology industry and agriculture Temperature 021001 nanoscience & nanotechnology Molecular Imaging Molecular Weight Chemical engineering chemistry Critical micelle concentration Drug delivery Nanoparticles 0210 nano-technology Macromolecule |
| Zdroj: | International journal of pharmaceutics. 556 |
| ISSN: | 1873-3476 |
| Popis: | Pluronics are triblock copolymers, in which two hydrophilic poly (ethylene oxide) (PEO) blocks are connected via a hydrophobic poly propylene oxide (PPO) block. Because of their low molecular weight and high content of PEO, Pluronics have demonstrated the micellization phenomenon, which is dependent on temperature and/or concentration. With an understanding of micellization phenomenon in more detail, information on the morphology, micelle core radius, aggregation behavior with critical micelle concentration (CMC) and critical micelle temperature (CMT) and so on has been revealed. Based on this acquired information, various studies have been performed for biomedical applications such as drug delivery systems, tissue regeneration scaffolders, and biosurfactants. This review discusses the delivery of small molecules and macromolecules using Pluronic-based NPs and their composites. |
| Databáze: | OpenAIRE |
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