Neurocognitive functioning in patients with first-episode schizophrenia: results of a prospective 15-year follow-up study
| Autor: | Helmut Küchenhoff, D Drießlein, S Pechler, W. Hubmann, F. Mohr, Margot Albus, T V Tiedemann |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Audiology Neuropsychological Tests Verbal learning Visual memory Task Performance and Analysis medicine Semantic memory Verbal fluency test Humans Pharmacology (medical) Cognitive Dysfunction Biological Psychiatry business.industry Neuropsychology General Medicine Middle Aged Verbal reasoning medicine.disease Prognosis Psychiatry and Mental health Psychotic Disorders Schizophrenia Disease Progression Female business Neurocognitive Follow-Up Studies |
| Zdroj: | European archives of psychiatry and clinical neuroscience. 270(6) |
| ISSN: | 1433-8491 |
| Popis: | To evaluate the course of neuropsychological impairment, patients with first-episode schizophrenia and healthy controls were assessed with a comprehensive test battery at the time of index treatment and after a 5- and 15-year follow-up period. Summary scores for verbal intelligence (VBI), spatial organization, verbal fluency, verbal learning, semantic memory, visual memory, delay/retention rate, short-term memory, visual-motor processing and attention (VSM) and abstraction/flexibility were constructed. Our results show that neurocognitive functioning is impaired already at the onset of schizophrenia and remains stable over the 15-year follow-up period with an improvement in VBI. With regard to the presence of a deficit syndrome, it became apparent that the group with a deficit syndrome showed a deterioration of neurocognitive functions during the follow-up period, most pronounced in VSM. On the other hand, the group without a deficit syndrome showed an improvement in neurocognitive functions at the 15-year follow-up, which exceeded the learning effects of healthy control subjects. Neurocognitive performance at index assessment strongly predicted the performance at the 15-year follow-up. Most likely due to the small sample size, there were only weak associations between treatment with different types of neuroleptics and neurocognitive performance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink