Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia
| Autor: | Jitlada Meephansan, Poonkiat Suchonwanit, Yong Poovorawan, Nawaporn Ungpraphakorn, Saranyoo Ponnikorn |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Stimulation Lasers Solid-State Dermatology Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences Insulin-like growth factor 0302 clinical medicine Internal medicine Biopsy medicine Humans RNA Messenger Insulin-Like Growth Factor I Wnt Signaling Pathway beta Catenin integumentary system medicine.diagnostic_test Chemistry Growth factor Wnt signaling pathway Alopecia General Medicine Middle Aged Wnt Proteins body regions medicine.anatomical_structure Endocrinology 030220 oncology & carcinogenesis Scalp Catenin Female Surgery Laser Therapy Wound healing |
| Zdroj: | Dermatologic Surgery. 44:1295-1303 |
| ISSN: | 1524-4725 1076-0512 |
| DOI: | 10.1097/dss.0000000000001619 |
| Popis: | Background A new treatment for androgenetic alopecia (AGA) is a 1,550-nm erbium-glass (Er:Glass) fractional laser. The wound healing process associated with this treatment is believed to be due to the stimulation of hair regrowth. Both the Wingless-related integration site (Wnt) proteins and insulin-like growth factor 1 (IGF-1) are important molecules that promote new hair growth. Objective The aim of this study was to evaluate the efficacy of 1,550-nm Er:Glass fractional laser treatment and determine the gene expression of IGF-1 and Wnt/β-catenin in patients with AGA. Methods Twenty-three patients with AGA were enrolled. They received 12 treatments at 2-week intervals. A scalp biopsy was performed to evaluate mRNA levels of Wnt10A and IGF-1. Histopathologic samples were collected. Results Significant increases in hair count and shaft diameter that occurred from Month 4 until the end of the study were observed. Histological results showed increases in the follicular unit, anagen hair count, and the anagen:telogen ratio. No up-regulation of Wnt10A and IGF-1 mRNA was observed. Conclusion The 1,550-nm Er:Glass fractional laser treatment can increase hair density and shaft diameter in patients with AGA. The mechanisms by which 1,550-nm Er:Glass laser treatment induces new hair growth may not be limited to Wnt10A/β-catenin or IGF-1 expression. |
| Databáze: | OpenAIRE |
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