Pregnancy outcomes decline with increasing recipient body mass index: an analysis of 22,317 fresh donor/recipient cycles from the 2008-2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry
| Autor: | Jason S. Yeh, James M. Goldfarb, Meredith P. Provost, Ryan G. Steward, Kelly S. Acharya, Suheil J. Muasher, Chaitanya R. Acharya, Jennifer L. Eaton |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Time Factors Pregnancy Rate Reproductive Techniques Assisted medicine.medical_treatment Fertilization in Vitro Body Mass Index 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors medicine Odds Ratio Humans Embryo Implantation Obesity Registries Pregnancy outcomes Retrospective Studies Gynecology 030219 obstetrics & reproductive medicine Assisted reproductive technology Oocyte Donation Obstetrics business.industry Obstetrics and Gynecology Retrospective cohort study General Medicine Odds ratio medicine.disease Confidence interval United States Pregnancy Complications 030104 developmental biology Fertility Logistic Models Treatment Outcome Reproductive Medicine Infertility Female Live birth business Body mass index Live Birth |
| Zdroj: | Fertility and sterility. 105(2) |
| ISSN: | 1556-5653 |
| Popis: | Objective To examine the effect of recipient body mass index (BMI) on IVF outcomes in fresh donor oocyte cycles. Design Retrospective cohort study. Setting Not applicable. Patient(s) A total of 22,317 donor oocyte cycles from the 2008–2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry were stratified into cohorts based on World Health Organization BMI guidelines. Cycles reporting normal recipient BMI (18.5–24.9) were used as the reference group. Intervention(s) None. Main Outcome Measure(s) Implantation rate, clinical pregnancy rate (PR), pregnancy loss rate, live birth rate. Result(s) Success rates and adjusted odds ratios with 95% confidence intervals for all pregnancy outcomes were most favorable in cohorts of recipients with low and normal BMI, but progressively worsened as BMI increased. Conclusion(s) Success rates in recipient cycles are highest in those with low and normal BMI. Furthermore, there is a progressive and statistically significant worsening of outcomes in groups with higher BMI with respect to clinical pregnancy and live birth rate. |
| Databáze: | OpenAIRE |
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