An Integrated View: Neuroadipocrinology of Diabesity
| Autor: | George N. Chaldakov, Marco Fiore, Luigi Aloe, Gorana Rančić, Neşe Tunçel, Jerzy Bełtowski |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
obesity
ngf bdnf Adipokine adipobiology Type 2 diabetes Bioinformatics Energy homeostasis gojaznost Neurotrophic factors Medicine neurobiologija adipokines Adiponectin diabetes dijabetes business.industry Leptin neurobiology adipokini Type 2 Diabetes Mellitus General Medicine medicine.disease adipobiologija metabotrophins Metabolic syndrome metabotrofini business |
| Zdroj: | Serbian Journal of Experimental and Clinical Research, Vol 15, Iss 2, Pp 61-69 (2014) |
| ISSN: | 1820-8665 |
| Popis: | 2 1 Laboratorija za biologiju celije, Katedra za anatomiju i histologiju, Medicinski Univerzitet, Varna, Bugarska 2 Institut za biologiju celije i neurobiologiju, Nacionalni istraživacki centar, Rim, Italija 3 Katedra za histologiju i embriologiju, Medicinski fakultet, Univerzitet u Nisu, Srbija 4 Katedra za patofi ziologiju, Medicinski Univerzitet, Lublin, Poljska 5 Katedra za fi ziologiju, Medicinski fakultet, Univerzitet Eskisehir Osmangazi, Eskisehir, Turska ABSTRACT Today's achievements in systems biology and -omics sciences have facilitated a shift from studying individual molecules and tissues to characterising molecules and cells holistically. In this article, we attempt to discuss the sta- tus of a much-needed coherent view that integrates stud- ies on neurobiology and adipobiology, as well as those on diabetes and obesity. Globally, cardiometabolic diseases (atherosclerosis, hypertension, type 2 diabetes mellitus, obesity, diabesity, and metabolic syndrome) are the most prevalent pathologies. In 2000, Astrup and Finer (Obes Rev 1: 57-59) wrote the following: "Since type 2 diabetes is obesity dependent, and obesity is the main aetiogical cause of type 2 diabetes, we propose the term 'diabesity' should be adopted." Arguably, the research field of adipo- biology has witnessed three major paradigm shifts since the discovery of leptin, an adipose-derived hormone, in 1994. Various neuroendocrine and neurotrophic factors are included in the growing list of endocrine and paracrine adipose-secreted signaling proteins collectively designated adipokines. These findings open a novel field of research known as neuroadipocrinology, a component of neuroen- docrinology. Adipokines, including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), mediate multiple biological processes, such as food intake, immunity, inflammation, memory, mood, and metabo- lism. The effects on metabolism involve the maintenance of glucose, lipid and energy homeostasis as well as cardio- protection, neuroprotection, and aging. In this article, we highlight the role of metabotrophic factors (MTF) and the adipose- and nonadipose-derived biomolecules that me- diate these effects. Recent results demonstrate that circu- lating and tissue levels of certain MTFs, e.g., adiponectin, NGF, BDNF, glucagon-like protein-1, sirtuin-1, interleu- kin-10, and aquaporin-7, are altered in cardiometabolic diseases, including diabesity. Overall, this may cultivate |
| Databáze: | OpenAIRE |
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