Abnormalities in Circulating Beta Cell Peptides in Chronic Renal Failure: Comparison of C-Peptide, Proinsulin and Insulin
| Autor: | Arthur H. Rubenstein, Hideshi Kuzuya, Jonathan B. Jaspan, David L. Horwitz, Mary E. Mako, Petra M. Blix |
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| Rok vydání: | 1977 |
| Předmět: |
Adult
Male medicine.medical_specialty Arginine Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Biochemistry chemistry.chemical_compound Endocrinology Diabetes mellitus Internal medicine medicine Humans Insulin Proinsulin Kidney C-Peptide business.industry C-peptide Biochemistry (medical) Middle Aged medicine.disease Glucose medicine.anatomical_structure Basal (medicine) chemistry Starvation Kidney Failure Chronic Female Beta cell Peptides business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 45:441-446 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-45-3-441 |
| Popis: | Serum insulin, proinsulin and C-peptidewere measured in six patients with chronicrenal failure and 12 controls in the fasting stateand following oral glucose and iv arginine. Fastinglevels of insulin (0.13 ± 0.05 nM vs. 0.05 ± 0.01 nM),proinsulin (0.12 ± 0.06 nM vs. 0.02 ± 0.01 nM) andC-peptide (3.35 ± 1.35 nM vs. 0.65 ± 0.26 nM) werehigher in patients with chronic renal failure than incontrols, the increase in proinsulin (7.5-fold) andC-peptide (4.9-fold) exceeding that of insulin (2.4-fold). Following glucose, insulin rose 11.7 times(60 min) in controls, while the increment in chronicrenal failure patients was less at 7.5-fold (90 min).C-peptide peaked at 3.7-fold (90 min) in controlsand fell toward basal levels at 240 min. In contrast,in chronic renal failure patients, C-peptide peakedlater (180 min) reaching levels of 7.51 nM (1.9-foldincrease), and at 240 min remained near maximumlevels (7.18 nM). The glucose stimulated C-peptidelevels in patients with chronic renal failure weresignificantly higher (... |
| Databáze: | OpenAIRE |
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