Impact of soymilk consumption on 2,4-dinitrofluorobenzene-induced contact hypersensitivity and gut microbiota in mice
| Autor: | Mitsuru Katase, Takao Nagano, Kazunobu Tsumura |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Allergy Chemokine CXCL2 Phytochemicals 030209 endocrinology & metabolism Gut flora Dermatitis Contact 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Dinitrofluorobenzene RNA Ribosomal 16S medicine Animals Edema Humans Food science SOY ISOFLAVONES Mice Inbred BALB C 030109 nutrition & dietetics Intestinal microorganisms integumentary system biology Bacteria Contact hypersensitivity Ear Isoflavones Saponins medicine.disease biology.organism_classification Triggering Receptor Expressed on Myeloid Cells-1 Diet Gastrointestinal Microbiome Soy Milk SSS Disease Models Animal chemistry Cytokines Female Food Science |
| Zdroj: | International journal of food sciences and nutrition. 70(5) |
| ISSN: | 1465-3478 |
| Popis: | Soymilk is rich in phytochemicals such as soy isoflavones (SIs) and soyasaponins (SSs). Dietary SIs and SSs display inhibitory effects on contact hypersensitivity (CHS), which was reported in a mouse model for allergic contact dermatitis (ACD); however, the beneficial effects of soymilk consumption on CHS remain unknown. Here, we studied the effects of drinking soymilk on CHS and gut microbiota. Soymilk consumption attenuated ear oedema and swelling, decreased the infiltration of Gr-1-positive cells into ear tissues, and reduced the production of chemokine (C-X-C motif) ligand 2 and triggering receptor expressed on myeloid cells-1 in ear tissues. The analysis of bacterial 16S ribosomal RNA gene sequences indicated that CHS caused changes in the gut microbiota structure and that consuming soymilk reduced these changes. These results suggest that soymilk consumption may be of therapeutic value for patients with ACD and may help control the balance of intestinal microbiota. |
| Databáze: | OpenAIRE |
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