Neuropeptide Y and Leptin in Patients with Obstructive Sleep Apnea Syndrome
| Autor: | Joaquín Durán-Cantolla, Mónica de la Peña, M. Bosch, Antoni Ladaria, Antonia Barceló, Alvar Agusti, Elena Llompart, Ferran Barbé, Lourdes Guerra |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Leptin
Male Pulmonary and Respiratory Medicine medicine.medical_specialty medicine.medical_treatment Positive pressure Critical Care and Intensive Care Medicine Statistics Nonparametric Internal medicine Intensive care mental disorders medicine Humans Neuropeptide Y Obesity Prospective Studies Continuous positive airway pressure Analysis of Variance Sleep Apnea Obstructive Continuous Positive Airway Pressure business.industry Middle Aged medicine.disease Neuropeptide Y receptor humanities respiratory tract diseases Obstructive sleep apnea Endocrinology Case-Control Studies business Body mass index Biomarkers |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 171:183-187 |
| ISSN: | 1535-4970 1073-449X |
| DOI: | 10.1164/rccm.200405-579oc |
| Popis: | Neuropeptide Y (NPY) and leptin are two peptides involved in the regulation of body weight, energy balance, and sympathetic tone. This study investigates the independent role of apneas and obesity on NPY and leptin plasma levels in patients with obstructive sleep apnea syndrome (OSAS). To this end we compared their values in 23 obese (body mass index30 kg/m2) and 24 nonobese (body mass index27 kg/m2) patients with OSAS, and in 19 obese and 18 nonobese control subjects without OSAS. Patients who used continuous positive airway pressure for more than 4 hours/night were reexamined 3 and 12 months later. We found that NPY levels were increased (p0.01) in patients with OSAS independently of obesity. Leptin levels were also increased in OSAS but this was mostly associated to obesity. Continuous positive airway pressure treatment reduced NPY levels in all patients and leptin levels only in nonobese patients (p0.01). We concluded that NPY and leptin plasma levels are increased in patients with OSAS. Yet, whereas the former appear independent of obesity, the latter are mostly associated with obesity. |
| Databáze: | OpenAIRE |
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