Infantile Anaphylaxis in Korea: a Multicenter Retrospective Case Study
| Autor: | Yong Ju Lee, Taek Ki Min, Woo Kyung Kim, You Hoon Jeon, Kyunguk Jeong, Kyung Won Kim, Yong Mean Park, Tae Won Song, Gwang Cheon Jang, Hyun Hee Kim, So-Yeon Lee, Kangmo Ahn, Bok Yang Pyun, Jeong Hee Kim, Yoon Hee Kim, Jihyun Kim, Soo Young Lee, Hye Yung Yum |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Epinephrine Histamine Antagonists Cardiovascular symptoms 03 medical and health sciences Immunology Allergic Disorders & Rheumatology 0302 clinical medicine First line therapy Internal medicine Republic of Korea medicine Animals Humans Clinical severity 030212 general & internal medicine Egg Hypersensitivity Anaphylaxis Retrospective Studies business.industry Medical record Infant Newborn Infant food and beverages General Medicine Allergens Immunoglobulin E medicine.disease Bronchodilator Agents Decision points Milk Editorial Food Child Preschool Milk specific immunoglobulin E Female Original Article Milk Hypersensitivity business Food Hypersensitivity medicine.drug |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 1011-8934 |
| Popis: | Background Anaphylaxis is increasing in young children. The aim of the present study was to analyze the clinical characteristics of anaphylaxis in Korean infants, with a focus on food triggers. Methods The study analyzed the medical records of infants aged 0 to 2 years old who had been diagnosed with anaphylaxis in 23 secondary or tertiary hospitals in Korea. Results We identified 363 cases of infantile anaphylaxis (66.9% male). Cutaneous symptoms were most prevalent (98.6%), followed by respiratory (83.2%), gastrointestinal (29.8%), and neurologic (11.6%) symptoms. Cardiovascular symptoms were noted in 7.7% of the cases. Most of the cases of anaphylaxis (338; 93.1%) were induced by foods. The most common trigger food was cow's milk and cow's milk products (43.8%), followed by hen's eggs (21.9%), walnuts (8.3%), wheat (7.7%), peanuts (4.8%), other nuts (3.0%), and fish (2.1%). In cow's milk-induced anaphylaxis cases, more than half the cases had cow's milk specific immunoglobulin E (sIgE) levels that were lower than the diagnostic decision points (DDPs), which is 5 kUA/L for those under the age of 1 and 15 kUA/L for those over the age of 1. In anaphylaxis induced by hen's egg, most of the cases (91.8%) had hen's egg sIgE levels that were higher than the DDP, which is 2 kUA/L for those under the age of 2 and 7 kUA/L for those over the age of 2. Of the infantile anaphylaxis cases, 46.8% had been treated with epinephrine, and 25.1% had been prescribed an epinephrine auto-injector. Conclusion Cow's milk is the most frequent trigger food of anaphylaxis in Korean infants. However, we found no significant correlation between the sIgE level and clinical severity. Education is required regarding the importance of epinephrine as the first line therapy for anaphylaxis and on properly prescribing epinephrine for infants with a history of anaphylaxis. Graphical Abstract |
| Databáze: | OpenAIRE |
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