Olfactory exposure to males, including men, causes stress and related analgesia in rodents
| Autor: | Gustaf Wigerblad, Basil Kadoura, Martina McPhail, Robert E. Sorge, Erinn L. Acland, Loren J. Martin, Wendy F. Sternberg, Alexander H. Tuttle, Ada Delaney, Jeffrey S. Wieskopf, Kelsey Isbester, Sarah F. Rosen, Philip Leger, Susana G. Sotocinal, Johannes Frasnelli, Alan P. Schumann, Anastassia Dokova, Josiane C.S. Mapplebeck, Jeffrey S. Mogil, Camilla I. Svensson, Tammie Quinn |
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| Rok vydání: | 2013 |
| Předmět: |
Male
business.industry Behavioral testing Physiology Pain Cell Biology Anatomy Affect (psychology) Olfactory Perception Biochemistry Rats Mice Stress Physiological Medicine Pain psychology Animals Humans Female Pain inhibition Analgesia business Molecular Biology Physiological stress Biotechnology Pain Measurement |
| Zdroj: | Nature methods. 11(6) |
| ISSN: | 1548-7105 |
| Popis: | We found that exposure of mice and rats to male but not female experimenters produces pain inhibition. Male-related stimuli induced a robust physiological stress response that results in stress-induced analgesia. This effect could be replicated with T-shirts worn by men, bedding material from gonadally intact and unfamiliar male mammals, and presentation of compounds secreted from the human axilla. Experimenter sex can thus affect apparent baseline responses in behavioral testing. |
| Databáze: | OpenAIRE |
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