Neuronorm is a potent and water soluble neurokinin A receptor antagonist
| Autor: | Vincenzo Pavone, Mario De Rosa, Francesco Rossi, Bruno D'Agostino, Maria Gabriella Matera, M. Falciani, Carlo Pedone, Amelia Filippelli, Angela Lombardi |
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| Přispěvatelé: | Lombardi, A, D'Agostino, Bruno, Filippelli, A, Pedone, C, Matera, Maria Gabriella, Falciani, M, DE ROSA, M, Rossi, F, Pavone, V., Lombardi, Angelina, D'Agostino, B, Pedone, Carlo, Matera, Mg, Rosa, Md, Pavone, Vincenzo, B., Dagostino, A., Filippelli, C., Pedone, M. G., Matera, M., Falciani, M., DE ROSA, F., Rossi |
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Clinical Biochemistry Guinea Pigs Pharmaceutical Science Pharmacology In Vitro Techniques Biochemistry Chemical synthesis Peptides Cyclic chemistry.chemical_compound Vas Deferens Internal medicine Drug Discovery medicine Peptide synthesis Animals Receptor Molecular Biology Organic Chemistry Vas deferens Antagonist Biological activity Receptors Neurokinin-2 respiratory system Receptor antagonist Rats Trachea medicine.anatomical_structure Endocrinology chemistry Molecular Medicine Neurokinin A |
| Zdroj: | Bioorganicmedicinal chemistry letters. 8(13) |
| ISSN: | 0960-894X |
| Popis: | We report here the synthesis and preliminary pharmacological characterization of a novel water soluble Neurokinin A receptor antagonist named Neuronorm. The synthesis was achieved in high yield by a combination of classical peptide synthesis methodologies, in both solution and solid phase. The pharmacological properties as neurokinin A receptor antagonist were assessed in in vitro experiments on rat vas deferens and guinea pig trachea, and were compared to those of MEN10627. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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