Programmable Metal/Semiconductor Nanostructures for mRNA-Modulated Molecular Delivery
| Autor: | Tanja Sack, Jagotamoy Das, Edward H. Sargent, Xiyan Li, Shana O. Kelley, Alexandre Zaragoza, Sae Rin Jean, Gordon Chan, Zongjie Wang, Libing Zhang, Sharif Uddin Ahmed |
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| Rok vydání: | 2018 |
| Předmět: |
Drug
media_common.quotation_subject Nanoparticle Metal Nanoparticles Bioengineering Nanotechnology 02 engineering and technology Drug resistance 010402 general chemistry 01 natural sciences Drug Delivery Systems Neoplasms Quantum Dots medicine Humans General Materials Science Doxorubicin RNA Messenger media_common Chemistry Mechanical Engineering Gene Transfer Techniques General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences Nanostructures Multiple drug resistance Semiconductors Quantum dot Drug Resistance Neoplasm Drug delivery Cancer cell Gold Multidrug Resistance-Associated Proteins 0210 nano-technology medicine.drug |
| Zdroj: | Nano letters. 18(10) |
| ISSN: | 1530-6992 |
| Popis: | Cytotoxic chemotherapeutics are important tools for the clinical treatment of a variety of solid tumors. However, their use is often complicated by multidrug resistance that can develop in patients, limiting the potencies of these agents. New strategies are needed to provide versatile systems that can respond to and disable resistance mechanisms. We demonstrate the use of a new family of materials, programmable metal/semiconductor nanostructures, for drug delivery and mRNA sensing in drug-resistant cells. These materials are composed of a central core gold nanoparticle surrounded by a layer of DNA-capped quantum dots. The modularity of these "core-satellite" assemblies allows for the construction of superstructures with controlled size and the incorporation of multiple functionalities for drug delivery. The DNA sequence within the nanoparticle specifically binds to an mRNA encoding an important drug resistance factor, MRP1, inside cancer cells, releasing a potent anticancer drug doxorubicin. This event triggers a turn-on fluorescence emission along with a downregulation of the MRP1 drug efflux pump, a main resistance factor for doxorubicin, yielding a remarkable improvement in therapeutic efficacy against drug-resistant cancer cells. This work paves the way for the development of programmable materials with multiple synergistic functionalities for biomedical applications. |
| Databáze: | OpenAIRE |
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