Cannabinoid receptor gene polymorphisms and cognitive performance in patients with schizophrenia and controls
| Autor: | Rafael Rodrigo dos Santos, Bruna Panizzutti, Antônio Lúcio Teixeira, Clarissa S. Gama, Rodrigo Ferretjans, Salvina Maria de Campos-Carli, Pâmela Ferrari, Fernanda Guimarães, João Vinícius Salgado, Lucas M. Mantovani, Renan P. Souza |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cannabinoid receptor
RC435-571 Neuropsychological Tests Bioinformatics Receptor Cannabinoid CB2 cannabinoids Cognition Receptor Cannabinoid CB1 cognitive dysfunction Medicine Verbal fluency test Humans Effects of sleep deprivation on cognitive performance endocannabinoids Genetic association Psychiatry Polymorphism Genetic CNR1 business.industry CNR2 medicine.disease Endocannabinoid system Psychiatry and Mental health Schizophrenia Case-Control Studies business Neurocognitive |
| Zdroj: | Brazilian Journal of Psychiatry, Issue: ahead, Published: 23 JUN 2021 Brazilian Journal of Psychiatry, Volume: 44, Issue: 1, Pages: 26-34, Published: 23 JUN 2021 Brazilian Journal of Psychiatry v.44 n.1 2022 Brazilian Journal of Psychiatry (São Paulo. 1999. Online) Associação Brasileira de Psiquiatria (ABP) instacron:ABP Brazilian Journal of Psychiatry (2021) |
| Popis: | Objective: To test the hypothesis that genetic variations of cannabinoid receptors contribute to the pathophysiology of cognitive deficits in schizophrenia. Methods: In this genetic association case-control study, cannabinoid receptor polymorphisms CNR1 rs12720071 and CNR2 rs2229579 were tested for association with neurocognitive performance in 69 patients with schizophrenia and 45 healthy controls. Neurocognition was assessed by the Brief Assessment of Cognition in Schizophrenia (BACS). Results: We found a consistent association between CNR1 rs12720071 polymorphism and the cognitive performance of patients in several cognitive domains. Patients with C/C polymorphism presented significantly worse performance in motor speed, verbal fluency, attention/processing speed and reasoning/problem solving. Conclusion: Although limited, our data support the hypothesis that CNR1 variations may be associated with the pathogenesis of cognitive deficits of schizophrenia. |
| Databáze: | OpenAIRE |
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