| Autor: |
Heverhagen, Johannes, Brügger, Lukas, Fattorini, Elisa, Büchler, Philippe, Abler, Daniel, Brusa, Tobia, Studer, Peter, Gingert, Christian, Tutuian, Radu |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Brusa, Tobia; Abler, Daniel; Tutuian, Radu; Studer, Peter; Fattorini, Elisa; Gingert, Christian; Heverhagen, Johannes; Brügger, Lukas; Büchler, Philippe (2017). MR-FLIP: A new method that combines FLIP with anatomical information for the spatial compliance assessment of the anal sphincter muscles. Colorectal disease, 19(8), pp. 764-771. Wiley 10.1111/codi.13588 |
| Popis: |
INTRODUCTION Continence results from a complex interplay between anal canal (AC) muscles and sensory-motor feedback mechanisms. The AC's passive ability to withstand opening pressure - its compliance - has recently been shown to correlate with continence. Functional lumen imaging probe (FLIP) is used to assess AC compliance, although it provides no anatomical information. Therefore, compliance assessment of specific anatomical structures has not been possible, and the anatomical position of critical functional zones remains unknown. In addition, FLIP assumes a circular orifice cross-section, which has not been shown for the AC. To address those shortcomings, a technique combining FLIP with a medical imaging modality is needed. METHOD We implemented a new research method (MR-FLIP) that combines FLIP with MR-imaging. Twenty healthy volunteers underwent MR-FLIP and conventional FLIP assessment. MR-FLIP was validated by comparison with FLIP results. Anatomical markers were identified, and the cross-sectional shape of the orifice was investigated. RESULTS MR-FLIP provides compliance measurements identical to those obtained by conventional FLIP. Anatomical analysis revealed that the least compliant AC zone was located at the proximal end of the external anal sphincter. The AC cross-sectional shape was found to deviate only slightly from circularity in healthy volunteers. CONCLUSION The proposed method was equivalent to classical FLIP. It establishes for the first time a direct mapping between local tissue compliance and anatomical structure, which is key for gaining novel insights into (in)continence. In addition, MR-FLIP provides a tool for better understanding conventional FLIP measurements in the AC by quantifying its limitations and assumptions. This article is protected by copyright. All rights reserved. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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