Involvement of BMP-2 signaling in a cartilage cap in osteochondroma
| Autor: | Kohji Kuriyama, Akira Myoui, Kozo Shimada, Susumu Joyama, Hideki Yoshikawa, Takanobu Nakase, Takahiro Miyaji, Tetsuya Tomita |
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| Rok vydání: | 2002 |
| Předmět: |
Osteochondroma
Male Pathology medicine.medical_specialty Bone Morphogenetic Protein 2 Bone Neoplasms Matrix (biology) Protein Serine-Threonine Kinases Bone morphogenetic protein Bone morphogenetic protein 2 Transforming Growth Factor beta medicine Humans Orthopedics and Sports Medicine Bone morphogenetic protein receptor Receptors Growth Factor RNA Messenger Child Bone Morphogenetic Protein Receptors Type I biology Chemistry Cartilage Mesenchymal stem cell Transforming growth factor beta medicine.disease medicine.anatomical_structure Child Preschool Bone Morphogenetic Proteins biology.protein Female Collagen |
| Zdroj: | Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 19(6) |
| ISSN: | 0736-0266 |
| Popis: | This study describes the distributions of bone morphogenetic protein (BMP)-2 as well as mRNAs for BMP receptor type IB (BMPRIB). collagen types II (Col II) and III (Col III) in a growing "cartilage cap" of osteochondroma. In situ hybridization and immunohistochemical study were performed using histological sections obtained during surgery. BMP-2 was detected in mesenchymal cells in the outer fibrous layer and chondrocytes in the inner cartilaginous matrix, positive for Col III and Col II, respectively. BMPRIB mRNA was distributed in chondrocytes. This is the first study to provide observational evidence of the involvement of BMP-2 signaling in the pathogenesis of cartilage cap of osteochondroma. and suggests the role of BMP-2 in the growth of cartilage cap in osteochondroma. |
| Databáze: | OpenAIRE |
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