Cadmium-Induced Effects on Bone in a Population-Based Study of Women
| Autor: | Jonas Lidfeldt, Christina Nerbrand, Marie Vahter, Thomas Lundh, Staffan Skerfving, Göran Samsioe, Per Bjellerup, Agneta Åkesson |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Deoxypyridinoline Bone density cadmium Health Toxicology and Mutagenesis Osteoporosis Population chemistry.chemical_element Bone and Bones Bone remodeling chemistry.chemical_compound Absorptiometry Photon Bone Density Internal medicine biochemical bone markers Humans Medicine education Sweden Bone mineral lead Cadmium education.field_of_study business.industry Research Public Health Environmental and Occupational Health Middle Aged medicine.disease osteoporosis Menopause Endocrinology chemistry Population Surveillance Multivariate Analysis Female women bone mineral density business |
| Zdroj: | Environmental Health Perspectives |
| ISSN: | 1552-9924 0091-6765 |
| Popis: | High cadmium exposure is known to cause bone damage, but the association between low-level cadmium exposure and osteoporosis remains to be clarified. Using a population-based women's health survey in southern Sweden [Women's Health in the Lund Area (WHILA) ] with no known historical cadmium contamination, we investigated cadmium-related effects on bone in 820 women (53-64 years of age) . We measured cadmium in blood and urine and lead in blood, an array of markers of bone metabolism, and forearm bone mineral density (BMD) . Associations were evaluated in multiple linear regression analysis including information on the possible confounders or effect modifiers: weight, menopausal status, use of hormone replacement therapy, age at menarche, alcohol consumption, smoking history, and physical activity. Median urinary cadmium was 0.52 microg/L adjusted to density (0.67 microg/g creatinine) . After multivariate adjustment, BMD, parathyroid hormone, and urinary deoxypyridinoline (U-DPD) were adversely associated with concentrations of urinary cadmium (p < 0.05) in all subjects. These associations persisted in the group of never-smokers, which had the lowest cadmium exposure (mainly dietary) . For U-DPD, there was a significant interaction between cadmium and menopause (p = 0.022) . Our results suggest negative effects of low-level cadmium exposure on bone, possibly exerted via increased bone resorption, which seemed to be intensified after menopause. Based on the prevalence of osteoporosis and the low level of exposure, the observed effects, although slight, should be considered as early signals of potentially more adverse health effects. Key words: biochemical bone markers, bone mineral density, cadmium, lead, osteoporosis, women. |
| Databáze: | OpenAIRE |
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