In vivo confocal microscopy of dermoscopic suspicious lesions in patients with xeroderma pigmentosum: A cross-sectional study
| Autor: | Cyro Festa-Neto, Paula Silva Ferreira, Caroline Colacique, Lilian Kelly Rocha, Silvia Vanessa Lourenço, Caroline de Freitas Barbosa, João Avancini |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Skin Neoplasms Xeroderma pigmentosum Adolescent Intravital Microscopy Cross-sectional study Confocal Dermoscopy Dermatology Malignancy Diagnosis Differential Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Humans Medicine Basal cell carcinoma Child Aged Retrospective Studies Skin Dermoepidermal junction Xeroderma Pigmentosum Microscopy Confocal business.industry Incidence (epidemiology) Melanoma Middle Aged medicine.disease Cross-Sectional Studies 030220 oncology & carcinogenesis Female business Follow-Up Studies |
| Zdroj: | Journal of the American Academy of Dermatology. 83:1668-1673 |
| ISSN: | 0190-9622 |
| DOI: | 10.1016/j.jaad.2019.12.018 |
| Popis: | Background Xeroderma pigmentosum (XP) is a rare genetic disease characterized by extreme photosensitivity, resulting in a higher incidence of cutaneous tumors. Reflectance confocal microscopy (RCM) is a noninvasive imaging method for diagnosing cutaneous lesions. Objective To explore the application of RCM in the follow-up of patients with XP. Methods Patients with XP underwent RCM for suspicious lesions from January 2010 through April 2019. Lesions with malignant RCM features were excised, and the results were compared with their histopathologic features. Benign lesions on RCM were monitored every 3 months. We recorded the confocal features that were related to malignancy and specifically to melanoma. Results A total of 61 suspicious lesions from 13 patients with XP were included. Thirty-three lesions (54%) were malignant (14 melanomas, 15 basal cell carcinomas, and 4 squamous cell carcinomas). Nonvisible papillae (OR, 11.8; 95% CI, 2.6-53.1; P = .001) and atypical cells at the dermoepidermal junction (OR, 11.7; 95% CI, 2.7-50.3; P = .001) were independent predictors of malignancy. Limitations There were limited numbers of patients and lesions. Most cases were retrospectively included, and some did not have a histologic analysis. Conclusions RCM is a valuable tool in the follow-up of patients with XP, reducing the need for excisions by 35%. |
| Databáze: | OpenAIRE |
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