Artificial Sweeteners in Animal Models of Binge Eating
| Autor: | Mary C. Olmstead, Gaëlle Awad, Katia Befort |
|---|---|
| Přispěvatelé: | Laboratoire de neurosciences cognitives et adaptatives (LNCA), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), univOAK, Archive ouverte |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
2. Zero hunger
0303 health sciences Binge eating 030309 nutrition & dietetics business.industry digestive oral and skin physiology medicine.disease Obesity Mental health Comorbidity Artificial Sweetener 3. Good health 03 medical and health sciences 0302 clinical medicine Binge-eating disorder medicine [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Animal studies medicine.symptom business Weight gain 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Animal Models of Eating Disorders Animal Models of Eating Disorders, 2020 Neuromethods ISBN: 9781071609231 Animal Models of Eating Disorders, 2020, ⟨10.1007/978-1-0716-0924-8_7⟩ |
| Popis: | Rising rates of obesity in most industrialized countries are a major cause of serious medical conditions, including diabetes, heart disease, and mental health disorders. Binge eating, characterized by excessive consumption of highly palatable food within a short period of time, contributes significantly to these problems, even in individuals who are not diagnosed with binge eating disorder (BED). Over the last half century, the use of non-nutritive substitutes has been promoted as a means to reduce fat and sugar consumption, potentially minimizing obesity-related illnesses. Paradoxically, increased intake of artificial sweeteners is associated with weight gain, which may be linked to alterations in metabolic processes. Artificial sweeteners also increase food intake in both humans and rodents, raising intriguing possibilities that these substances are altering biological processes that underlie the homeostatic control of feeding. We explore this idea by summarizing the clinical and preclinical literature on behavioral and biological mechanisms of artificial sweeteners. As a starting point, we review evidence that non-nutritive sweeteners are rewarding in rodent models, then provide a comparison of neural systems mediating the rewarding properties of natural and artificial sweeteners. We then summarize data pointing to sexual dimorphism in behavioral and biological responses to sucrose, with preliminary evidence suggesting that responses to artificial sweeteners may follow a similar pattern. Finally, we provide an overview of the relationship between binge eating and substance use disorders, noting findings from animal studies that artificial sweeteners could contribute to this comorbidity. |
| Databáze: | OpenAIRE |
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