Use and Discontinuation of Insulin Treatment Among Adults Aged 75 to 79 Years With Type 2 Diabetes
| Autor: | Kasia J. Lipska, Pranita Mishra, Neda Laiteerapong, Andrew J. Karter, Elbert S. Huang, Anjali Gopalan, Richard W. Grant, Jonathan Z. Weiner |
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| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
Male Pediatrics medicine.medical_specialty medicine.medical_treatment Disease Type 2 diabetes 01 natural sciences 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal Medicine medicine Humans Hypoglycemic Agents Insulin Dementia Longitudinal Studies 030212 general & internal medicine 0101 mathematics Aged Original Investigation Glycemic Glycated Hemoglobin business.industry 010102 general mathematics medicine.disease Discontinuation Diabetes Mellitus Type 2 Withholding Treatment Relative risk Female business |
| Zdroj: | JAMA Intern Med |
| ISSN: | 2168-6106 |
| Popis: | IMPORTANCE: Among older individuals with type 2 diabetes, those with poor health have greater risk and derive less benefit from tight glycemic control with insulin. OBJECTIVE: To examine whether insulin treatment is used less frequently and discontinued more often among older individuals with poor health compared with those in good health. DESIGN, SETTING, AND PARTICIPANTS: This longitudinal cohort study included 21 531 individuals with type 2 diabetes followed for up to 4 years starting at age 75 years. Electronic health record data from the Kaiser Permanente Northern California Diabetes Registry was collected to characterize insulin treatment and glycemic control over time. Data were collected from January 1, 2009, through December 31, 2017, and analyzed from February 2, 2018, through June 30, 2019. EXPOSURES: Health status was defined as good (2 comorbidities or 2 comorbidities and no self-reported weekly exercise), or poor (having end-stage pulmonary, cardiac, or renal disease; diagnosis of dementia; or metastatic cancer). MAIN OUTCOMES AND MEASURES: Insulin use prevalence at age 75 years and discontinuation among insulin users over the next 4 years (or 6 months prior to death if |
| Databáze: | OpenAIRE |
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