Effects of Traditional Chinese Medicinal Plants on Anti-insulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells
| Autor: | Gang Xu, Selena Ahmed, Hong-Xi Xu, Lixin Yang, Li-Lan Deng, Jun-Zeng Ma, Ji-Huan Qin, Dayuan Xue, Jiang-Xia Ye, Xiao-Ling Shen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Anti-insulin resistance bioactivity
Plant Science Toxicology Biochemistry Analytical Chemistry Insulin resistance Diabetes mellitus medicine Traditional medicinal plants Medicinal plants DXMS-induced insulin resistant HepG2 cells ComputingMethodologies_COMPUTERGRAPHICS Pharmacology Traditional medicine business.industry Organic Chemistry Diabetes Insulin resistant Insulin sensitivity medicine.disease Hepg2 cells Ethnobotany Original Article History of use business Food Science |
| Zdroj: | Natural Products and Bioprospecting |
| ISSN: | 2192-2209 2192-2195 |
| Popis: | Medicinal plants have a long history of use in China to treat diabetic symptoms. Ancient Chinese medical manuscripts and ethnobotanical surveys document plant remedies that continue to be actively used in China for the treatment of diabetic symptoms. Based on a systematic ancient Chinese medical manuscripts review in combination with ethnobotanical survey, 16 medicinal plants for the traditional treatment of diabetic symptoms were identified for the evaluation of anti-insulin resistance bioactivity. The biological activity of 16 medicinal plants was tested on dexamethasone (DXMS)-induced insulin resistant HepG2 cells. The result shows that 11 of the 16 medicinal plants enhanced glucose uptake of DXMS-induced insulin resistant HepG2 cells, thereby demonstrating their ability to increase insulin sensitivity, other five medicinal plants including Astragalus membranaceus were found ineffective. The study shows that ancient Chinese medical manuscripts and ethnobotanical surveys on plants for the prevention and treatment of diabetic symptoms provide a promising knowledge base for drug discovery to mitigate the global diabetes epidemic. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink