Myelodysplastic Syndromes with Bone Marrow Fibrosis: An Update

Autor:	Akriti G. Jain, Ling Zhang, John M. Bennett, Rami Komrokji
Rok vydání:	2022
Předmět:	Primary Myelofibrosis Risk Factors Myelodysplastic Syndromes Biochemistry (medical) Clinical Biochemistry Humans General Medicine Prognosis
Zdroj:	Annals of Laboratory Medicine. 42:299-305
ISSN:	2234-3814 2234-3806
Popis:	Myelodysplastic syndrome (MDS) is a diverse hematological malignancy with a wide spectrum of presentations and implications. Treatment strategies for patients with MDS heavily rely on prognostic scoring systems, such as the revised international prognostic scoring system (IPSS-R). Bone marrow fibrosis (BMF) has been identified as an independent risk factor for poor survival in patients with MDS, irrespective of the IPSS-R risk category. However, BMF is not widely included in scoring systems and is not always considered by clinicians when making treatment decisions for patients. In this review, we discuss the available literature about the presentation and prognosis of patients with MDS and concurrent BMF. The prognostic impact of BMF should be factored in when deciding on transplant candidacy, especially for intermediate-risk patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2be3c01dfca717d0782ff2837cbfbde https://doi.org/10.3343/alm.2022.42.3.299 Zobrazit plný text záznamu