Oncogenic GOPC-ROS1 Fusion Identified in a Congenital Glioblastoma Case
| Autor: | Derek A Mathis, Brent A. Orr, Susan L Whiteway, Aaron M. Betts, Adam L. Green, Ahmed Gilani, Erika R O'Neil |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
ROS1 Fusion
Oncogene Proteins Fusion medicine.medical_treatment Brain tumor medicine.disease_cause Pathogenesis 03 medical and health sciences 0302 clinical medicine Proto-Oncogene Proteins medicine Humans Adaptor Proteins Signal Transducing Chemotherapy Mutation business.industry Brain Neoplasms Infant Newborn Golgi Matrix Proteins Hematology Protein-Tyrosine Kinases medicine.disease Prognosis nervous system diseases Oncology 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Cancer research Molecular targets Molecular Profile Female business Glioblastoma 030215 immunology |
| Zdroj: | Journal of pediatric hematology/oncology. 42(8) |
| ISSN: | 1536-3678 |
| Popis: | Congenital glioblastoma (GBM) is a rare brain tumor of infancy. While histologically they resemble pediatric and adult GBM, growing evidence suggests a distinct molecular profile. We report the case of a 7-day-old infant female with congenital GBM found to harbor a GOPC-ROS1 fusion. She underwent surgical resection, moderate-intensity chemotherapy without radiation, and remains disease-free 4 years from completion of therapy. While the frequency of this mutation is not known, the identification of this oncogenic driver may provide insight into the pathogenesis of GBM in this age group and may serve as a molecular target for select patients. |
| Databáze: | OpenAIRE |
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