Capsaicin 8% dermal patch in clinical practice: an expert opinion
| Autor: | Anthony H. Dickenson, Vittorio Guardamagna, Giorgio Cruccu, Amedeo Costantini, Cesare Bonezzi, Enrico Polati, Vincenzo Palmieri, Pierangelo Zini, Diego Fornasari |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Administration Topical Cost-Benefit Analysis Pregabalin TRPV1 TRPV Cation Channels Transdermal Patch fibers Neuropathic pain 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Humans Pharmacology (medical) Expert Testimony Pharmacology Analgesics business.industry General Medicine Dermal patch Dermatology topical treatment Tolerability chemistry Topical Capsaicin 030220 oncology & carcinogenesis Administration Nociceptor Quality of Life Neuralgia Onset of action TRPV1 receptors business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Expert opinion on pharmacotherapy. 21(11) |
| ISSN: | 1744-7666 |
| Popis: | Introduction Neuropathic pain (NP) is caused by a lesion or disease of the somatosensory system, which can severely impact patients' quality of life. The current-approved treatments for NP comprise of both centrally acting agents and topical drugs, including capsaicin 8% dermal patches, which is approved for the treatment of peripheral NP. Areas covered The authors summarize literature data regarding capsaicin use in patients who suffer from NP and discuss the clinical applications of this topical approach. Expert opinion Overall, the capsaicin 8% dermal patch is as effective in reducing pain intensity as other centrally active agents (i.e. pregabalin). Some studies have also reported fewer systemic side effects, a faster onset of action and superior treatment satisfaction compared with systemic agents. In our opinion, capsaicin 8% dermal patches also present additional advantages, such as a good systemic tolerability, the scarcity of adverse events, the possibility to combine it with other agents, and a good cost-effective profile. It is important to note that, as the mechanism of action of capsaicin 8% is the 'defunctionalization' of small afferent fibers through interaction with TRPV1 receptors, the peripheral expression of this receptor on nociceptor fibers, is crucial to predict patient's response to treatment. |
| Databáze: | OpenAIRE |
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