Nitric Oxide and Endothelin 1 during Postnatal Life
| Autor: | Masaaki Takada, Mamoru Ayusawa, Michiyoshi Minato, Shigeru Takahashi, Akihiko Endo, Kazuo Sato, Naoki Masaoka, Masami Shimada, Kensuke Harada |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Aging
medicine.medical_specialty Vasodilation Endogeny Nitric Oxide Nitric oxide chemistry.chemical_compound Reference Values Internal medicine Humans Medicine Nitrites Nitrates Endothelin-1 business.industry Infant Newborn Biological activity Fetal Blood medicine.disease Pulmonary hypertension Endothelin 1 Endocrinology medicine.anatomical_structure chemistry Recien nacido Pediatrics Perinatology and Child Health business Developmental Biology Blood vessel |
| Zdroj: | Neonatology. 70:15-20 |
| ISSN: | 1661-7819 1661-7800 |
| Popis: | Nitric oxide (NO) is a potent vasodilator produced by endothelial cells. Endothelin 1 (ET-1), another agent made by endothelial cells, is the most potent vasoconstrictor known to date. Endogenous NO and ET-1 may play a part in the normal physiological pulmonary vascular changes during the postnatal period. However, the changes of NO and ET-1 in healthy neonates have not been defined. We determined serum NO metabolites, i.e., nitrites and nitrates, and plasma ET-1 in 19 healthy neonates at birth (cord blood) and at ages 5 and 30 days. The sums of serum nitrite and nitrate (NOx) levels were 27.5 ± 12.8,53.8 ± 14.2, and 38.3 ± 13.2 μmol/l at birth, age 5 days, and age 30 days, respectively. The plasma ET-1 concentrations were 3.9 ± 1.6, 1.1 ± 0.2, and 1.1 ± 0.2 × 106 μmol/l at birth, age 5 days, and age 30 days, respectively. These changes in healthy neonates suggest the presence of active physiological roles for NO and ET-1 in circulatory adaptation to extra-uterine life. |
| Databáze: | OpenAIRE |
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