Glycogen synthase kinase 3β in tumorigenesis and oncotherapy (Review)
| Autor: | Tiantian Lei, Yi Wang, Xiaofang Xie, Rui He, Suya Du |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research oncotherapy Carcinogenesis Cellular differentiation GSK 3β inhibitors Cell Apoptosis Review macromolecular substances Biology medicine.disease_cause Mice 03 medical and health sciences Antineoplastic Agents Immunological 0302 clinical medicine GSK-3 Neoplasms Antineoplastic Combined Chemotherapy Protocols medicine Animals Humans Lymphocytes Phosphorylation Protein Kinase Inhibitors Glycogen Synthase Kinase 3 beta Oncogene Kinase Cell growth General Medicine Cell cycle Gene Expression Regulation Neoplastic Disease Models Animal tumorigenesis glycogen synthase kinase 3β 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Proteolysis Disease Progression Cancer research Signal Transduction Transcription Factors |
| Zdroj: | Oncology Reports |
| ISSN: | 1791-2431 1021-335X |
| DOI: | 10.3892/or.2020.7817 |
| Popis: | Glycogen synthase kinase 3β (GSK 3β), a multifunctional serine and threonine kinase, plays a critical role in a variety of cellular activities, including signaling transduction, protein and glycogen metabolism, cell proliferation, cell differentiation, and apoptosis. Therefore, aberrant regulation of GSK 3β results in a broad range of human diseases, such as tumors, diabetes, inflammation and neurodegenerative diseases. Accumulating evidence has suggested that GSK 3β is correlated with tumorigenesis and progression. However, GSK 3β is controversial due to its bifacial roles of tumor suppression and activation. In addition, overexpression of GSK 3β is involved in tumor growth, whereas it contributes to the cell sensitivity to chemotherapy. However, the underlying regulatory mechanisms of GSK 3β in tumorigenesis remain obscure and require further in-depth investigation. In this review, we comprehensively summarize the roles of GSK 3β in tumorigenesis and oncotherapy, and focus on its potentials as an available target in oncotherapy. |
| Databáze: | OpenAIRE |
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