CNS activity of Alstonia macrophylla leaf extracts: an ethnomedicine of Onge of Bay Islands
| Autor: | G. Arunachalam, Asit Baran Mandal, Lopamudra Ghosh, Debprasad Chattopadhyay |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Central Nervous System
Male Flavonoid India Pain Fractionation Pharmacognosy Mice Drug Discovery Botany Animals Tannin Pharmacology chemistry.chemical_classification Analgesics Behavior Animal biology Traditional medicine Plant Extracts Alkaloid General Medicine biology.organism_classification Antidepressive Agents Sterol Rats Plant Leaves Alstonia macrophylla Neuromuscular Agents Phytochemical chemistry Female Medicine Traditional Sleep Alstonia Phytotherapy |
| Zdroj: | Fitoterapia. 75:673-682 |
| ISSN: | 0367-326X |
| DOI: | 10.1016/j.fitote.2004.08.002 |
| Popis: | Methanol extract at 100-200 mg/kg p.o. and major nonpolar fraction B at 50 mg/kg of Alstonia macrophylla leaves caused a significant reduction in spontaneous activity, remarkable decrease in exploratory behavioural pattern, a reduction in muscle relaxant activity and also significantly potentiated phenobarbitone sodium-induced sleeping time. The phytochemical study of crude leaf extract revealed the presence of tannin, triterpenoid, flavonoid, sterol, alkaloid and reducing sugars. Further fractionation and purification of the n-butanol part of methanol extract yielded fraction A, fraction B and fraction C along with some minor fatty acids as the major compounds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect