Haematological and immunological effects of repeated dose exposure of rats to integerrimine N-oxide from Senecio brasiliensis
| Autor: | Fabiana Elias, Fernando Pípole, Silvana Lima Górniak, Mitsue Haraguchi, Andréia Oliveira Latorre, Isis Machado Hueza |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Lymphoid Tissue Neutrophils Lymphocyte Immunotoxicology Pharmacology Toxicology Blood cell chemistry.chemical_compound Immune system Immunity medicine Animals Senecio Rats Wistar Pyrrolizidine Alkaloids Immunity Cellular PLANTAS TÓXICAS Dose-Response Relationship Drug biology Plant Extracts Cell Cycle General Medicine biology.organism_classification Rats Dose–response relationship medicine.anatomical_structure chemistry Antibody Formation Pyrrolizidine Immunology Senecio brasiliensis Food Science |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 0278-6915 |
| Popis: | This study is the first in the literature to focus attention on the possible immunotoxic effect of integerrimine N-oxide content in the butanolic residue (BR) of Senecio brasiliensis, a poisonous hepatotoxic plant that contains pyrrolizidine alkaloids (PAs). PAs have been reported as a pasture and food contaminant and as herbal medicine used worldwide and are responsible for poisoning events in livestock and human beings. After the plant extraction, BR extracted from Senecio brasiliensis was found to contain approximately 70% integerrimine N-oxide by elemental and spectral analyses ((1)H and (13)C NMR), which was administered to adult male Wistar Hannover rats at doses of 3, 6 and 9 mg/kg for 28 days. Body weight gain, food consumption, lymphoid organs, neutrophil analysis, humoural immune response, cellular immune response and lymphocyte analysis were evaluated. Our study showed that integerrimine N-oxide could promote an impairment in the body weight gain, interference with blood cell counts and a reducing T cell proliferative activity in rats; however, no differences in the neutrophil activities, lymphocytes phenotyping and humoural and cellular immune responses were observed. It is concluded that doses of integerrimine N-oxide here employed did not produce marked immunotoxic effects. |
| Databáze: | OpenAIRE |
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