Novel Metabolic Markers for the Risk of Diabetes Development in American Indians

Autor: Karan Uppal, Barbara V. Howard, Dean P. Jones, Elisa T. Lee, Tianwei Yu, Jiang He, Noorie Hyun, Jinying Zhao, ViLinh Tran, Donglin Zeng, Yun Zhu
Rok vydání: 2014
Předmět:
Adult
Male
medicine.medical_specialty
Diabetes risk
Endocrinology
Diabetes and Metabolism
Metabolite
030209 endocrinology & metabolism
Type 2 diabetes
Logistic regression
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Insulin resistance
Risk Factors
Diabetes mellitus
Internal medicine
Internal Medicine
medicine
Humans
Metabolomics
Prospective Studies
Prospective cohort study
030304 developmental biology
Advanced and Specialized Nursing
0303 health sciences
business.industry
Biphenyl Compounds
Fasting
Health Disparities in Diabetes
medicine.disease
Isoflavones
3. Good health
Biphenyl compound
Logistic Models
Endocrinology
Diabetes Mellitus
Type 2
chemistry
Indians
North American
Phosphatidylcholines
Female
Insulin Resistance
business
Oligopeptides
Biomarkers
Zdroj: Diabetes Care
ISSN: 1935-5548
0149-5992
DOI: 10.2337/dc14-2033
Popis: OBJECTIVE To identify novel metabolic markers for diabetes development in American Indians. RESEARCH DESIGN AND METHODS Using an untargeted high-resolution liquid chromatography–mass spectrometry, we conducted metabolomics analysis of study participants who developed incident diabetes (n = 133) and those who did not (n = 298) from 2,117 normoglycemic American Indians followed for an average of 5.5 years in the Strong Heart Family Study. Relative abundances of metabolites were quantified in baseline fasting plasma of all 431 participants. Prospective association of each metabolite with risk of developing type 2 diabetes (T2D) was examined using logistic regression adjusting for established diabetes risk factors. RESULTS Seven metabolites (five known and two unknown) significantly predict the risk of T2D. Notably, one metabolite matching 2-hydroxybiphenyl was significantly associated with an increased risk of diabetes, whereas four metabolites matching PC (22:6/20:4), (3S)-7-hydroxy-2′,3′,4′,5′,8-pentamethoxyisoflavan, or tetrapeptides were significantly associated with decreased risk of diabetes. A multimarker score comprising all seven metabolites significantly improved risk prediction beyond established diabetes risk factors including BMI, fasting glucose, and insulin resistance. CONCLUSIONS The findings suggest that these newly detected metabolites may represent novel prognostic markers of T2D in American Indians, a group suffering from a disproportionately high rate of T2D.
Databáze: OpenAIRE
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