Incremental value of FDG-PET/CT to monitor treatment response in infectious spondylodiscitis
| Autor: | Fernando Di Gregorio, Barbara Cadeo, Maria Merelli, Matteo Bassetti, Giulia Melchioretto, Elda Righi, Abass Alavi, Daniele Muser, Alessia Carnelutti |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Spondylodiscitis Quantitative FDG uptake analysis Treatment response Discitis Standardized uptake value Sensitivity and Specificity 030218 nuclear medicine & medical imaging Lesion 03 medical and health sciences 0302 clinical medicine Cohen's kappa Fluorine-18-fluorodeoxyglucose positron emission tomography Infectious spondylodiscitis MRI Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography medicine Humans Radiology Nuclear Medicine and imaging Aged Retrospective Studies 030203 arthritis & rheumatology business.industry Retrospective cohort study Middle Aged medicine.disease Magnetic Resonance Imaging Response to treatment Anti-Bacterial Agents Disease Progression Female Fdg pet ct Radiopharmaceuticals medicine.symptom business Nuclear medicine |
| Zdroj: | Skeletal Radiology. 49:903-912 |
| ISSN: | 1432-2161 0364-2348 |
| Popis: | To assess the added value of serial 2-deoxy-2-[18F]fluoro-D-glucose (FDG) uptake analysis in predicting clinical response to treatment in infectious spondylodiscitis (IS). We sought to analyze changes in quantitative FDG-PET/CT parameters among patients with clinical response or treatment failure and to compare the sensitivity and specificity of serial FDG-PET/CT and MRI in predicting treatment response in IS. This retrospective study consisted of 68 FDG-PET/CT examinations in 34 patients performed before and after at least 2 weeks of antibiotic treatment. Serial MRI scans were available in 32 (94%) patients before and after treatment. FDG-avid lesions were quantified as maximum standardized uptake value (SUVmax), partial-volume corrected lesion metabolic volume (LMV), and partial-volume corrected lesion metabolic activity (LMA). All FDG-PET/CT parameters significantly decreased in patients with clinical improvement (31/34, 91%, P 15% and > 25% showed 94% and 89% sensitivity and 67% and 100% specificity compared with 37% and 50% of MRI, respectively. Low degree of agreement with clinical response was shown for MRI compared with FDG-PET/CT parameters using the Cohen kappa coefficient. FDG-PET/CT monitoring is a valuable tool to predict clinical response to treatment in IS and has greater sensitivity and specificity compared with MRI. |
| Databáze: | OpenAIRE |
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