Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities
| Autor: | Yeonjoong Yong, Young Han Lee, Yoonkyung Woo, Yoongho Lim, Jiye Hyun, Soon Young Shin, Dongsoo Koh |
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| Rok vydání: | 2011 |
| Předmět: |
Models
Molecular Chalcone Clinical Biochemistry Flavonoid Anti-Inflammatory Agents Pharmaceutical Science Antineoplastic Agents Inhibitory postsynaptic potential Biochemistry Structure-Activity Relationship chemistry.chemical_compound Cell Line Tumor Drug Discovery Humans Structure–activity relationship heterocyclic compounds Molecular Biology Flavonoids chemistry.chemical_classification Tumor Necrosis Factor-alpha fungi Organic Chemistry NF-kappa B food and beverages NF-κB chemistry Cell culture Colonic Neoplasms Molecular Medicine Tumor necrosis factor alpha Flavanone |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 21:6036-6041 |
| ISSN: | 0960-894X |
| Popis: | It has been previously shown that some flavonoids inhibit NF-κB; however, the structure-activity relationships between chalcone, flavanone, flavone, and isoflavone derivatives and their TNFα induced NF-κB inhibitory effects on HCT116 human colon cancer cells have not yet been reported. Therefore, in this study, the effects of flavonoid structure on inhibition of NF-κB were investigated. Based on the combined results of this study, the structure of the flavonoids was shown to affect NF-κB activation. |
| Databáze: | OpenAIRE |
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