Decreased mortality in acute pancreatitis related to early aggressive hydration
| Autor: | Ian Wall, Kadirawel Iswara, Robin Baradarian, Nison Badalov, Scott Tenner, Jianjun Li |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Necrosis Time Factors Endocrinology Diabetes and Metabolism Gastroenterology Endocrinology Intravenous hydration Internal medicine Internal Medicine medicine Humans Intensive care medicine Infusions Intravenous Survival rate Aged Hepatology business.industry Pancreatitis Acute Necrotizing Middle Aged medicine.disease Survival Rate medicine.anatomical_structure Pancreatitis Acute Disease Disease Progression Acute pancreatitis Fluid Therapy Female Intravascular volume depletion medicine.symptom Pancreas business Perfusion |
| Zdroj: | Pancreas. 40(4) |
| ISSN: | 1536-4828 |
| Popis: | Early aggressive intravenous hydration is believed to prevent morbidity and mortality by preventing intravascular volume depletion and maintaining perfusion of the pancreas possibly preventing pancreatic necrosis. The following study was initiated to determine the relationship between the observed decrease in mortality and the role of early aggressive hydration.A consecutive series of patients with acute pancreatitis from a single community hospital in 1998 were compared to a consecutive series of patients with acute pancreatitis from the same institution in 2008.Significantly more patients developed pancreatic necrosis; 26 (15%) of 173 patients in 1998 compared to 4 (4%) of 113 patients in 2008. The mean rate of hydration was significantly higher in 2008 compared with that in 1998 (P = 0.02). In 1998, hydration was provided at 184 mL/h during the first 6 hours and 188 mL/h during the first 12 hours compared with 284 mL/h during the first 6 hours and 221 mL/h during the first 12 hours in 2008. There was a significant decrease in mortality in 2008 compared with that in 1998 (3.5% vs 12%, P = 0.03).The decrease in mortality seen in patients with acute pancreatitis during the last decade may be related to the increased aggressive hydration preventing pancreatic necrosis. |
| Databáze: | OpenAIRE |
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