Cefaclor: in vitro spectrum of activity and beta-lactamase stability
| Autor: | Kwung P. Fu, Harold C. Neu |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
medicine.drug_class
medicine.medical_treatment Cephalosporin Microbial Sensitivity Tests Serratia Microbiology Amidohydrolases Drug Stability Physiological Effects and Microbial Susceptibility Haemophilus medicine polycyclic compounds Pharmacology (medical) Cephalosporinase Pharmacology biology Bacteria Chemistry Acinetobacter biology.organism_classification Anti-Bacterial Agents Cephalosporins Proteus Infectious Diseases Beta-lactamase Bacteroides Cefaclor medicine.drug |
| Zdroj: | Antimicrobial agents and chemotherapy. 13(4) |
| ISSN: | 0066-4804 |
| Popis: | The in vitro activity of cefaclor against 556 clinical isolates of gram-positive and gram-negative bacteria was compared with that of other cephalosporins. Cefaclor had activity similar to that of cephalexin against gram-positive bacteria. It showed greater activity against Haemophilus strains than did cephalexin and inhibited β-lactamase-producing Haemophilus isolates. Cefaclor was more active than cephalexin or cephalothin against Escherichia coli, Salmonella, and Shigella isolates but did not act against Serratia, Acinetobacter, indole-positive Proteus, or Bacteroides isolates. Cefaclor was resistant to type III (TEM) β-lactamases but was destroyed by type I β-lactamases and, to a lesser degree, by type IV and type V β-lactamases. |
| Databáze: | OpenAIRE |
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