Chemical and Toxicity Studies of Trichodesma africanum L
| Autor: | Omar M, Youngken Hw, DeFeo J |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Chemical Phenomena Potassium Compounds Pharmaceutical Science Poison control medicine.disease_cause Analytical Chemistry Toxicology Mice chemistry.chemical_compound Alkaloids Drug Discovery medicine Animals Toxins Biological Plant Poisoning Pharmacology Nitrates Stigmasterol biology Traditional medicine Toxin Alkaloid Organic Chemistry Hemodynamics Boraginaceae Saponins biology.organism_classification Rats Chemistry Plants Toxic Trichodesma Complementary and alternative medicine chemistry Toxicity Pyrrolizidine Molecular Medicine Peptides |
| Zdroj: | Journal of Natural Products. 46:153-156 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np50026a001 |
| Popis: | Trichodesma africanum L. (Boraginaceae), a desert plant of Africa and Asia, was found to contain beta-amyrin, beta-methyl oleanate, potassium nitrate and a nitrogen-containing toxin, each producing a notable toxic response when injected in laboratory mice and rats. Muscle contraction and a blood pressure reduction caused by the toxin are described. Pyrrolizidine alkaloids, e.g., trichodesmine, present in other Trichodesma species were also identified in the material by tlc and spectrometric methods. These did not, however, produce the acute toxic effects observed for the nonalkaloid compounds mentioned above. beta-Sitosterol and stigmasterol were identified as the principal sterols in the plant. Language: en |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|